DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano3

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_001121575.1	Gene:	Ano3 / 228432	MGIID:	3613666	Length:	981	Species:	Mus musculus

Alignment Length:	1001	Identity:	369/1001 - (36%)
Similarity:	529/1001 - (52%)	Gaps:	142/1001 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 TSQRFL--DQEQLSASRESLGAADKRARFAESNAPTL-------QLPESAEPRANGKRPTGNRTN 139
            ||..||  |:.:...|.||...:..:..||:.:...|       .|.||.....:..|...:...
Mouse    68 TSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVT 132

  Fly   140 PSNPAAPL-LPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRIN 203
            ...||:.. |...|..::                        .::.|.|:|..:.||::|.||
Mouse   133 KDKPASKTKLSKNDMSYI------------------------ASSGLLFKDGKKRIDYILVYR-- 171

  Fly   204 AHEPTELENTEKRRVFEANLISQGLEVESS---QKDQIWFVKIHAPLEVLRRYAEILKLRMPMKE 265
               .|.:: .:||..||.||.::||.:|..   ....|.|:|||.|.:.|.:|||.|.:|:|
Mouse   172 ---KTNIQ-YDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVP--- 229

  Fly   266 SLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRN-IYVDEEIFP--K 327
                         .|...:|...|       |:|...|.:..|.:.::..:| :.:|:..||  :
Mouse   230 -------------FRKKCYYTDQK-------NKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELE 274

  Fly   328 RAHRFTAIYSRDKEYLFDI-RQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMA-FGIERLIAEGV 390
            .:..:|..:||.:.:.|.| .:|.||:.|.|||||..:|:|.::    ::.:: .||.:||..|.
Mouse   275 ESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKY----ENGISKVGIRKLITNGS 335

  Fly   391 YSAAYPLHDG------EITETGTM--RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLG 447
            |.||:|.|:|      .|...|..  |.|||:.||....||::||||.|:.|||.||||||||||
Mouse   336 YIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLG 400

  Fly   448 YYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDW-CNFWDLKETCNYAKV 511
            :||.||:.|::||:..|.|...::......::||::  |.:.||||||. |:...|.::|.||||
Mouse   401 WYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKA--TEVFMCPLCDKNCSLQRLNDSCIYAKV 463

  Fly   512 TYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLA---RLEHIP 573
            |||.||..|||||:||:.|||:|||.|||..:.:|:.|||..::..||..|||:.|   |:|.|.
Mouse   464 TYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVIN 528

  Fly   574 PTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYR---MSMLAALKVGAS 635
            |     :|...||..|. ..|:...:.|.|.:..:|:|...|:.||||||   |...|:.|..
Mouse   529 P-----ITGKPEPHQPS-SDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWN-- 585

  Fly   636 PMTTSSAIVLATASAAF-VNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVN 699
              ........||:.||. :|..::.:||..|..:|..||.||..||::::::|..||::|.||||
Mouse   586 --FVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVN 648

  Fly   700 YYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYL 763
            ..:||||||||.|:||||||:|||||: :|.|||...|||.:||:|:.:||..||.:|..:|:..
Mouse   649 LNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGY 713

  Fly   764 PMF--WRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIF 826
            |:.  |.....|:.|:          ..|...:|..|:.|......||..||||||||:||.|||
Mouse   714 PLIQNWWSRHKIKRGI----------QDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIF 768

  Fly   827 VAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAF 891
            ||||||||..||||||:|:||||.|.:|..:||:..|..|||:|..||:.||.|:||||.|:||.
Mouse   769 VAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAI 833

  Fly   892 TSDMIPRLVY--------RHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITT-----C 943
            |||.|||.||        .|....:..|.||:|.:||.|             |||.:..     |
Mouse   834 TSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFF-------------DLSELGMGKSGYC 885

  Fly   944 RYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREV 1008
            ||.|:|.||.|.:.|..:..::.|||.||.|::|||:.|..:...:.:.|||:...||::||||.
Mouse   886 RYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREK 950

  Fly  1009 YVTNEIIIDQEAHRARFERAKRSSSV 1034
            |:..|::.:.|....:.:|.|....:
Mouse   951 YLVQEMMYEAELEHLQQQRRKSGQPI 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	79/257 (31%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	260/599 (43%)
Ano3	NP_001121575.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..87		7/18 (39%)
		Anoct_dimer	157..381	CDD:292796	79/256 (31%)
		Anoctamin	384..950	CDD:282414	261/600 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5559
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860