Protein Alignment subdued and ANO5

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_998764.1
• Gene: ANO5 / 203859
• HGNCID: 27337
• Length: 913
• Species: Homo sapiens
• Alignment Length: 884
• Identity: 345/884 - (39%)
• Similarity: 515/884 - (58%)
• Gaps: 93/884 - (10%)

  Fly   175 FYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVE-----SSQ 234
            |.:..:...|:||.|.:|.|||||:|..:..:..||: .|:|:.||.||...|||:|     .|:
Human    61 FQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELK-AERRKEFETNLRKTGLELEIEDKRDSE 124

  Fly   235 KDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRS 299
            ..:.:|||||||.|||..|||:|.::||:|||                      .||
Human   125 DGRTYFVKIHAPWEVLVTYAEVLGIKMPIKES----------------------DIP-------- 159

  Fly   300 TKSVFSSLKHV-FQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIR-QDCFFTTAVRSRIVE 362
                  ..||. ..:.|..:.:...:.......|||.:||.::.||.|. |..||.::.|:|||.
Human   160 ------RPKHTPISYVLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVY 218

  Fly   363 FILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETG------TMRALLYKHWASVPK 421
            :||.|..|..:: ....||||||:....||:|||||||:..:..      ..|..|:::||....
Human   219 YILSRCPFGIED-GKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSY 282

  Fly   422 WYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDIC--QSG 484
            :|:.||||.||.|:|.|||:||.:||:||.||..|::||:.||:|...|:::.....:||  :.|
Human   283 FYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIG 347

  Fly   485 NTNITMCPLCDW-CNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHR 548
            ...| ||||||. |::|.|..||..:|.::|.||.||||||:||..|.|||||.||:..|.:.:.
Human   348 GQMI-MCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYE 411

  Fly   549 WDLTGFDVHEE--HPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIAL 611
            |||..|:..::  ..||::.|..:|   .:::.||...||.:|.: .::|....|.:.|.|.::|
Human   412 WDLVDFEEEQQQLQLRPEFEAMCKH---RKLNAVTKEMEPYMPLY-TRIPWYFLSGATVTLWMSL 472

  Fly   612 AFVALLAVVVYRMSMLAALKVGASPMTTSSAI----------VLATASAAFVNLCLLYILNYMYN 666
            ...:::||:|||:|:.|..   ||.|.:.:::          :..:.:.:.:|..::.|||:.|.
Human   473 VVTSMVAVIVYRLSVFATF---ASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYE 534

  Fly   667 HLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF-DYRQE 730
            .::.::|::|:.||..:::.|||||::|.||||:|:|.||:|||||||||:||:|..|| ::|.|
Human   535 KISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSE 599

  Fly   731 ECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPM---FWRKVLAIQVGLSRLFNNTPNPDKAKD 792
            ||..||||.||..||.|||.|||.|..|.|...|:   :||:..| :....:|::
Human   600 ECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKA-RTNSEKLYS---------- 653

  Fly   793 ERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHK 857
             ||.:|..|..:|..|||.||||.|.|:||||:|||:|||||..||:|||:|:|:||.||.|.::
Human   654 -RWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYR 717

  Fly   858 RPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGT--LDGYLNFTLS 920
            |.|:.:...||||..||..:..|||.||.||:|||||:||||||.:..:...|  :.||:|.:||
Human   718 RTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNSLS 782

  Fly   921 EFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALV 985
            .|.:.|.|. ::...:..:..||||.|:|.||....||..:..|:.:||.::.|::|.|:.|.||
Human   783 VFLIADFPN-HTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIVMEHVVFLV 846

  Fly   986 MILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRAR 1024
            ..|:.|.|||:..::.::|:||..:|.:|:.|.|.::.:
Human   847 KFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLK 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	87/254 (34%)
		Anoctamin	431..1007	CDD:461349	247/596 (41%)
ANO5	NP_998764.1	Anoct_dimer	72..289	CDD:465044	87/254 (34%)
		Anoctamin	292..868	CDD:461349	247/596 (41%)
		COG5594	<462..>583	CDD:227881	43/123 (35%)