DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ANO5

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_998764.1	Gene:	ANO5 / 203859	HGNCID:	27337	Length:	913	Species:	Homo sapiens

Alignment Length:	884	Identity:	345/884 - (39%)
Similarity:	515/884 - (58%)	Gaps:	93/884 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 FYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVE-----SSQ 234
            |.:..:...|:||.|.:|.|||||:|..:..:..||: .|:|:.||.||...|||:|     .|:
Human    61 FQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELK-AERRKEFETNLRKTGLELEIEDKRDSE 124

  Fly   235 KDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRS 299
            ..:.:|||||||.|||..|||:|.::||:|||                      .||
Human   125 DGRTYFVKIHAPWEVLVTYAEVLGIKMPIKES----------------------DIP-------- 159

  Fly   300 TKSVFSSLKHV-FQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIR-QDCFFTTAVRSRIVE 362
                  ..||. ..:.|..:.:...:.......|||.:||.::.||.|. |..||.::.|:|||.
Human   160 ------RPKHTPISYVLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVY 218

  Fly   363 FILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETG------TMRALLYKHWASVPK 421
            :||.|..|..:: ....||||||:....||:|||||||:..:..      ..|..|:::||....
Human   219 YILSRCPFGIED-GKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSY 282

  Fly   422 WYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDIC--QSG 484
            :|:.||||.||.|:|.|||:||.:||:||.||..|::||:.||:|...|:::.....:||  :.|
Human   283 FYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIG 347

  Fly   485 NTNITMCPLCDW-CNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHR 548
            ...| ||||||. |::|.|..||..:|.::|.||.||||||:||..|.|||||.||:..|.:.:.
Human   348 GQMI-MCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYE 411

  Fly   549 WDLTGFDVHEE--HPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIAL 611
            |||..|:..::  ..||::.|..:|   .:::.||...||.:|.: .::|....|.:.|.|.::|
Human   412 WDLVDFEEEQQQLQLRPEFEAMCKH---RKLNAVTKEMEPYMPLY-TRIPWYFLSGATVTLWMSL 472

  Fly   612 AFVALLAVVVYRMSMLAALKVGASPMTTSSAI----------VLATASAAFVNLCLLYILNYMYN 666
            ...:::||:|||:|:.|..   ||.|.:.:::          :..:.:.:.:|..::.|||:.|.
Human   473 VVTSMVAVIVYRLSVFATF---ASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYE 534

  Fly   667 HLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF-DYRQE 730
            .::.::|::|:.||..:::.|||||::|.||||:|:|.||:|||||||||:||:|..|| ::|.|
Human   535 KISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSE 599

  Fly   731 ECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPM---FWRKVLAIQVGLSRLFNNTPNPDKAKD 792
            ||..||||.||..||.|||.|||.|..|.|...|:   :||:..| :....:|::
Human   600 ECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKA-RTNSEKLYS---------- 653

  Fly   793 ERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHK 857
             ||.:|..|..:|..|||.||||.|.|:||||:|||:|||||..||:|||:|:|:||.||.|.::
Human   654 -RWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYR 717

  Fly   858 RPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGT--LDGYLNFTLS 920
            |.|:.:...||||..||..:..|||.||.||:|||||:||||||.:..:...|  :.||:|.:||
Human   718 RTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNSLS 782

  Fly   921 EFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALV 985
            .|.:.|.|. ::...:..:..||||.|:|.||....||..:..|:.:||.::.|::|.|:.|.||
Human   783 VFLIADFPN-HTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIVMEHVVFLV 846

  Fly   986 MILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRAR 1024
            ..|:.|.|||:..::.::|:||..:|.:|:.|.|.::.:
Human   847 KFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLK 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	87/254 (34%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	247/596 (41%)
ANO5	NP_998764.1	Anoct_dimer	72..289	CDD:374413	87/254 (34%)
ANO5	NP_998764.1	Anoctamin	292..868	CDD:367984	247/596 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm8665
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.920