Protein Alignment subdued and ANO4

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_011536213.2
• Gene: ANO4 / 121601
• HGNCID: 23837
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 1163
• Identity: 408/1163 - (35%)
• Similarity: 596/1163 - (51%)
• Gaps: 199/1163 - (17%)

  Fly     3 NLGSAKVGALEEATSPPPFSKDESFQLLERSPH--NPAISPTTTVPLEPP--------------- 50
            ||.||..|:.....|......|.:..:.....|  ||.:....|:|.:.|
Human    48 NLSSATTGSYYSCVSQITIGYDVAGPVAIGLTHWKNPYVQGRPTLPSDLPLFVSKDAGIPVYHRS 112

  Fly    51 FT------TPLA-PFDMELMKRHNLHERLTGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRA 108
            ||      |||: |..:.          :|...|:   ..:||..|.|:....|. |:..|:||.
Human   113 FTRKTDQATPLSCPASLS----------ITPVPSY---SSSSQETLSQDTTGLSL-SIHGAEKRL 163

  Fly   109 RF------AESNAPTLQLP-----------ESAEPRANGKRPTGNRTNPSNPAA----------- 145
            :.      |...|...:||           .|.:..|:....|..:|...:|..
Human   164 QIHQRRSVASRPASRRRLPVVRHSSLPPGRRSIKMEASSSGITNGKTKVFHPEGGVDLQGYQLDM 228

  Fly   146 ---PLLPMTDPDF---------VKGNVGGVYDDRE-----CSCPREFYQRGEINTS--------- 184
               |..|.:|.||         :..:|..::|:.|     |.........|.:.::
Human   229 QILPDGPKSDVDFSEILNAIQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEA 293

  Fly   185 -------------LFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQ-- 234
                         |:|.|....||::|.||.:..:      ||||.|||.|:.::||::|...
Human   294 GGETVPERNKSNGLYFRDGKCRIDYILVYRKSNPQ------TEKREVFERNIRAEGLQMEKESSL 352

  Fly   235 -KDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNR 298
             ...|.|||:|||.|||.||||.:.:|||.:..:                :||..:...||.:::
Human   353 INSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKI----------------YYLPRRYKFMSRIDK 401

  Fly   299 STKSVFSSLKHVFQFFL--RNIYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQDCFFTTAVRS 358
            ....        |:.:|  :.:.:|:|..|.....  :||.:|:.:.:.|.| .::.||..|.||
Human   402 QISR--------FRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRS 458

  Fly   359 RIVEFILDRQRF-PAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRA--------LLYK 414
            |||..||.|.:: ..||:    .|:.||:..|.|.||:|||:|......::|.        |||:
Human   459 RIVHHILQRIKYEEGKNK----IGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYE 519

  Fly   415 HWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKD 479
            .|||...||:|||||.::.|||.||||||||||:||.||..|:.:|:..|||...:|.:....|:
Human   520 CWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKE 584

  Fly   480 ICQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSA 543
            :||:  |:|.|||:|| :|.|..|.::|.|||||:|.||.:||||||||:.|||:|||.|||..|
Human   585 VCQA--TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRA 647

  Fly   544 EITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLL 608
            .|.:.|||..::..||..|||:.|:  :....|::.::...||...| ..|....:.|.|.:..:
Human   648 VIAYDWDLIDWEEEEEEIRPQFEAK--YSKKERMNPISGKPEPYQAF-TDKCSRLIVSASGIFFM 709

  Fly   609 IALAFVALLAVVVYR---MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAE 670
            |.:...|:..:|:||   :|..||.|..   :..:::.|..|.:|..:|.|::.:||.:|..:|.
Human   710 ICVVIAAVFGIVIYRVVTVSTFAAFKWA---LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVAL 771

  Fly   671 YLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSS 734
            .||.||..||::::::|.|||::|.||||..:|.||||||.|:|.||||.|.:|.: :|.|||..
Human   772 LLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHP 836

  Fly   735 GGCLTELCIQLAIIMVGKQAFNTILEVYLPM---FW-RKVLAIQVGLSRLFNNTPNPDKAKDERW 795
            .|||.:||:|:.||||.||.:|..:|:..|:   :| |:.:..:.|..|         |....:|
Human   837 SGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPER---------KISFPQW 892

  Fly   796 MRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPV 860
            .:|:.|....|.|||.|||||:||:||.|||||||||||..||||||:|:||||.|.:|..:||:
Human   893 EKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPL 957

  Fly   861 SQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK--------QGTLDGYLNF 917
            :.|.:|||:||.||:.||.||||||.|:||.|||.||||||.:....        |..:.||:|.
Human   958 ASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNA 1022

  Fly   918 TLSEFKVIDSPTLYSLAGDLSN-----ITTCRYTDFRLPPSS--PEKYTLSSMFYIILACRLGFV 975
            :||.|::.|.........|.|.     :..|||.|:|.||.|  |..|||  .|:.:||.||.|:
Human  1023 SLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTL--QFWHVLAARLAFI 1085

  Fly   976 VVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSS 1033
            :|||:.|..:..|:.:.|||:..:|||::|||.|:..|::.:.|..|.:.||.:|..:
Human  1086 IVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKN 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	84/258 (33%)
		Anoctamin	431..1007	CDD:461349	262/599 (44%)
ANO4	XP_011536213.2	Anoct_dimer	308..533	CDD:465044	84/258 (33%)
		Anoctamin	536..1117	CDD:461349	262/599 (44%)