DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment subdued and ANO4

DIOPT Version :9

Sequence 1:NP_001189248.1 Gene:subdued / 42340 FlyBaseID:FBgn0038721 Length:1099 Species:Drosophila melanogaster
Sequence 2:XP_011536213.1 Gene:ANO4 / 121601 HGNCID:23837 Length:1121 Species:Homo sapiens


Alignment Length:1163 Identity:408/1163 - (35%)
Similarity:596/1163 - (51%) Gaps:199/1163 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NLGSAKVGALEEATSPPPFSKDESFQLLERSPH--NPAISPTTTVPLEPP--------------- 50
            ||.||..|:.....|......|.:..:.....|  ||.:....|:|.:.|               
Human    17 NLSSATTGSYYSCVSQITIGYDVAGPVAIGLTHWKNPYVQGRPTLPSDLPLFVSKDAGIPVYHRS 81

  Fly    51 FT------TPLA-PFDMELMKRHNLHERLTGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRA 108
            ||      |||: |..:.          :|...|:   ..:||..|.|:....|. |:..|:||.
Human    82 FTRKTDQATPLSCPASLS----------ITPVPSY---SSSSQETLSQDTTGLSL-SIHGAEKRL 132

  Fly   109 RF------AESNAPTLQLP-----------ESAEPRANGKRPTGNRTNPSNPAA----------- 145
            :.      |...|...:||           .|.:..|:....|..:|...:|..           
Human   133 QIHQRRSVASRPASRRRLPVVRHSSLPPGRRSIKMEASSSGITNGKTKVFHPEGGVDLQGYQLDM 197

  Fly   146 ---PLLPMTDPDF---------VKGNVGGVYDDRE-----CSCPREFYQRGEINTS--------- 184
               |..|.:|.||         :..:|..::|:.|     |.........|.:.::         
Human   198 QILPDGPKSDVDFSEILNAIQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEA 262

  Fly   185 -------------LFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQ-- 234
                         |:|.|....||::|.||.:..:      ||||.|||.|:.::||::|...  
Human   263 GGETVPERNKSNGLYFRDGKCRIDYILVYRKSNPQ------TEKREVFERNIRAEGLQMEKESSL 321

  Fly   235 -KDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNR 298
             ...|.|||:|||.|||.||||.:.:|||.:..:                :||..:...||.:::
Human   322 INSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKI----------------YYLPRRYKFMSRIDK 370

  Fly   299 STKSVFSSLKHVFQFFL--RNIYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQDCFFTTAVRS 358
            ....        |:.:|  :.:.:|:|..|.....  :||.:|:.:.:.|.| .::.||..|.||
Human   371 QISR--------FRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRS 427

  Fly   359 RIVEFILDRQRF-PAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRA--------LLYK 414
            |||..||.|.:: ..||:    .|:.||:..|.|.||:|||:|......::|.        |||:
Human   428 RIVHHILQRIKYEEGKNK----IGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYE 488

  Fly   415 HWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKD 479
            .|||...||:|||||.::.|||.||||||||||:||.||..|:.:|:..|||...:|.:....|:
Human   489 CWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKE 553

  Fly   480 ICQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSA 543
            :||:  |:|.|||:|| :|.|..|.::|.|||||:|.||.:||||||||:.|||:|||.|||..|
Human   554 VCQA--TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRA 616

  Fly   544 EITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLL 608
            .|.:.|||..::..||..|||:.|:  :....|::.::...||...| ..|....:.|.|.:..:
Human   617 VIAYDWDLIDWEEEEEEIRPQFEAK--YSKKERMNPISGKPEPYQAF-TDKCSRLIVSASGIFFM 678

  Fly   609 IALAFVALLAVVVYR---MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAE 670
            |.:...|:..:|:||   :|..||.|..   :..:::.|..|.:|..:|.|::.:||.:|..:|.
Human   679 ICVVIAAVFGIVIYRVVTVSTFAAFKWA---LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVAL 740

  Fly   671 YLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSS 734
            .||.||..||::::::|.|||::|.||||..:|.||||||.|:|.||||.|.:|.: :|.|||..
Human   741 LLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHP 805

  Fly   735 GGCLTELCIQLAIIMVGKQAFNTILEVYLPM---FW-RKVLAIQVGLSRLFNNTPNPDKAKDERW 795
            .|||.:||:|:.||||.||.:|..:|:..|:   :| |:.:..:.|..|         |....:|
Human   806 SGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPER---------KISFPQW 861

  Fly   796 MRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPV 860
            .:|:.|....|.|||.|||||:||:||.|||||||||||..||||||:|:||||.|.:|..:||:
Human   862 EKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPL 926

  Fly   861 SQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK--------QGTLDGYLNF 917
            :.|.:|||:||.||:.||.||||||.|:||.|||.||||||.:....        |..:.||:|.
Human   927 ASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNA 991

  Fly   918 TLSEFKVIDSPTLYSLAGDLSN-----ITTCRYTDFRLPPSS--PEKYTLSSMFYIILACRLGFV 975
            :||.|::.|.........|.|.     :..|||.|:|.||.|  |..|||  .|:.:||.||.|:
Human   992 SLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTL--QFWHVLAARLAFI 1054

  Fly   976 VVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSS 1033
            :|||:.|..:..|:.:.|||:..:|||::|||.|:..|::.:.|..|.:.||.:|..:
Human  1055 IVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKN 1112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
subduedNP_001189248.1 Anoct_dimer 186..428 CDD:292796 84/258 (33%)
Anoctamin 431..1007 CDD:282414 262/599 (44%)
ANO4XP_011536213.1 Anoct_dimer 277..502 CDD:292796 84/258 (33%)
Anoctamin 505..1087 CDD:282414 263/600 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 126 1.000 Domainoid score I5411
eggNOG 1 0.900 - - E1_KOG2514
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48769
OrthoDB 1 1.010 - - D1263362at2759
OrthoFinder 1 1.000 - - FOG0000156
OrthoInspector 1 1.000 - - mtm8665
orthoMCL 1 0.900 - - OOG6_100405
Panther 1 1.100 - - O PTHR12308
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1964
SonicParanoid 1 1.000 - - X144
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.860

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