DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano1

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_006508521.1	Gene:	Ano1 / 101772	MGIID:	2142149	Length:	1066	Species:	Mus musculus

Alignment Length:	1077	Identity:	390/1077 - (36%)
Similarity:	561/1077 - (52%)	Gaps:	218/1077 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LDQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPR--ANGKRPTGNRTNPSNPAAPLLPMT 151
            |..|..||.||.....:..|..|: :|.|   |.|.:..  .:|:|....|. |...:.  ||..
Mouse    14 LTPEGTSADRECQRGPETIAHEAQ-DAGT---PNSGDATGVVDGEREATMRV-PEKYST--LPAE 71

  Fly   152 DPDFVKGNVGGVYD------------------DRECSCPREFYQRGEINTSLFFEDCVRSIDFVL 198
            |......|:..:.|                  |.||            ...|:|.|..|.:|::|
Mouse    72 DRSVHIVNICAIEDLGYLPSEGTLLNSLSVDPDAEC------------KYGLYFRDGKRKVDYIL 124

  Fly   199 AYR--------------------------------------INAHEPT------ELENTEKRRVF 219
            .|.                                      ::|..|.      |.:...:|..:
Mouse   125 VYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLPGKGSPVDAGSPEVPMDYHEDDKRFRREEY 189

  Fly   220 EANLISQGLEVESSQKDQI---WFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRN 281
            |.||:..|||:|:.:..:|   .|||||||..||.|.||.|||:||.|:.   ..|||
Mouse   190 EGNLLEAGLELENDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTKKV---YHISE------- 244

  Fly   282 AAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAH-------RFTAIYSRD 339
                              |:.:..::..|.|      .:.:.|.||.|.       |.:..:||:
Mouse   245 ------------------TRGLLKTINSVLQ------KITDPIQPKVAEHRPQTTKRLSYPFSRE 285

  Fly   340 KEYLFDIR-QDCFFTTAVRSRIVEFILDRQRFPAKNQHDMA--------------------FGIE 383
            |::|||:. :|.||.:..||.||..||.|... .|.::.|.                    :||.
Mouse   286 KQHLFDLTDRDSFFDSKTRSTIVYEILKRTTC-TKAKYSMGQGEGRRKDSALLSKRRKCGKYGIT 349

  Fly   384 RLIAEGVYSAAYPLHDGEITETGTM---RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAW 445
            .|:|.||||||||||||:.......   |.|||:.|||...:|:|||:|.:::|||.|:||||||
Mouse   350 SLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWASYGVFYKYQPIDLVRKYFGEKVGLYFAW 414

  Fly   446 LGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETCNYA 509
            ||.||.||:.|||||||.|||...::...:|..::|.. ..||||||||| .|::|.:...|..|
Mouse   415 LGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMCDQ-RYNITMCPLCDKTCSYWKMSSACATA 478

  Fly   510 KVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEE----HPRPQYLARL- 569
            :.::|.|||:||||:|||:.||..|:|.|||....:.:|||||||:..||    |||.:|.||:
Mouse   479 RASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVL 543

  Fly   570 --------------EHIPPTRVDYVTNIKEPTVPF--------------------WRMKLPATVF 600
                          .::|          :|||..:                    ||.:.||...
Mouse   544 EKSLRKESRNKEKCRNVP----------EEPTNKWKQRVRTAMAGVKLTDKVKLTWRDRFPAYFT 598

  Fly   601 SFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMY 665
            :...::.:||:.|..:|.|::||:|..|||.:.:||...|:..|..||:|..:||.::.:|:.:|
Mouse   599 NLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVY 663

  Fly   666 NHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF-DYRQ 729
            ..:|.:||::|:.:|:..|::.||.|.:||:|||.|..|||:|||||:|||.||:|..:| .:|.
Mouse   664 GCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRM 728

  Fly   730 EECSSGGCLTELCIQLAIIMVGKQAF-NTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDK---A 790
            |||:.||||.||||||:|||:|||.. |.:.|:.:|...:.:..:     :|...:|:..:   .
Mouse   729 EECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYL-----KLRRQSPSDREEYVK 788

  Fly   791 KDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTH 855
            :.:|:..||.|..:.  ||.|||:||::|:||||:|||:|||||.|||||||:|:||||||.:|.
Mouse   789 RKQRYEVDFNLEPFA--GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTE 851

  Fly   856 HKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLS 920
            .:|||:.|.:|||:||.||..:|||:||.|.|:|:||||.||||||.:..::.||:.|::|.|||
Mouse   852 LRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYLYMYSQNGTMHGFVNHTLS 916

  Fly   921 EFKVID--SPTLYSLAGDLS-NITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFV 982
            .|.|.|  :.|..:...||. .:..|||.|:|.||.|..||.:|..|:.:||.||.||:||:|.|
Mouse   917 SFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLV 981

  Fly   983 ALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQE 1019
            ..:...|.|.|||:..::..||.:|..:..|:.:.:|
Mouse   982 MFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREE 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	91/319 (29%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	269/623 (43%)
Ano1	XP_006508521.1	Anoct_dimer	112..397	CDD:374413	91/319 (29%)
Ano1	XP_006508521.1	Anoctamin	400..1006	CDD:367984	269/623 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I320
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75079
Inparanoid	1	1.050	620	1.000	Inparanoid score	I879
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		otm43787
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910