DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano5a

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_021326432.1	Gene:	ano5a / 100534737	ZFINID:	ZDB-GENE-091013-2	Length:	931	Species:	Danio rerio

Alignment Length:	1040	Identity:	363/1040 - (34%)
Similarity:	554/1040 - (53%)	Gaps:	170/1040 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SQRFLDQEQLSASRESLGAADKRARF-AESNAPTLQLPESAE---PRANGKRPTGNRTNPSNPAA 145
            ||:..|:..:..||.:..:.:....| :.|:..|.|| |:||   .||.
Zfish     5 SQKSSDETLIEMSRTAWSSGEDNNGFHSNSDKETFQL-ENAEIWRKRAL---------------- 52

  Fly   146 PLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTEL 210
                     |:|      |..|       ..::.:...|::|.|.||.|||||:|   ..:....
Zfish    53 ---------FLK------YRSR-------VDKQQQSKDSVYFRDGVRRIDFVLSY---IDDKDGE 92

  Fly   211 ENTEKRRVFEANLISQGLEVESSQKDQ-----IWFVKIHAPLEVLRRYAEILKLRMPMKESLCNL 270
            :..::|:||||||...|||||:..|.:     .:|:|||.|.|||..||::||:::|.|
Zfish    93 KKQDRRKVFEANLQKAGLEVETEDKSESEDGKTYFLKIHVPWEVLATYADVLKIKVPFK------ 151

  Fly   271 RISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAI 335
                            .|.||       ..|.:  .:..:|..|    .:.:.:.......||:.
Zfish   152 ----------------ANDIP-------ENKEI--PMGWLFTPF----RLPDHVMNPEPDFFTST 187

  Fly   336 YSRDKEYLFDIR-QDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHD 399
            :.:.|...|.|. ::..|..:.|:|||.::|  .|.|...:.....||:||:..|.|::|:||||
Zfish   188 FDKSKIDFFLIEDKETLFPASTRNRIVYYLL--SRIPYSTEDKDKKGIKRLLNNGTYTSAFPLHD 250

  Fly   400 ------GEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASI 458
                  .......:.|..|||:||....:|:.|||:.|::|:|.|||:||||||:||.||..|::
Zfish   251 CRYWTRSRDDNCESERYSLYKNWARFSSFYKEQPLNLIRKYYGEKIGIYFAWLGFYTEMLSYAAV 315

  Fly   459 VGVICFLYSWFSLKNYVPVKDIC-QSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTV 521
            ||::||:|...:....:..::|| ::....|.|||||| .|.:|.|..||:.:..:||.||.:||
Zfish   316 VGLLCFIYGVATFDENIWSREICNETIGGQIVMCPLCDKKCGYWKLSTTCSSSWQSYLFDNAATV 380

  Fly   522 FFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEE--HPRPQYLARLEHIPPTRVDYVTNIK 584
            |||:||..|.|||||.|||..|.:.:.|||..|:..::  ..||:|.::..:   .|::.||..:
Zfish   381 FFAIFMGIWVTLFLEFWKRRQARLEYEWDLVDFEEEQQQLQLRPEYESKCTN---RRLNRVTQEQ 442

  Fly   585 EPTVPFWRM-KLPAT-----VFSFSVVLLLIALAFVALLAVVVYRMSMLAA------------LK 631
            |     |.: :.||.     |..::.|||.|:|...:::.|:.||:::.||            |:
Zfish   443 E-----WVLDQTPADKAGRFVLCWTTVLLWISLIIASIIGVIAYRLAVFAAFASIMKDSPTNKLE 502

  Fly   632 VGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQ 696
            :..:.:|...|   .:.:|:.:|..::.:||::|..:|..:|::|:.:|..::::.||:|::|.|
Zfish   503 IVGNLITPQFA---TSVTASCINFVIIMVLNFLYERVAIKITDMEVPKTHVEYENKLTIKMFLFQ 564

  Fly   697 FVNYYASIFYIAFFKGKFVGHPGEYNKLF----DYRQEECSSGGCLTELCIQLAIIMVGKQAFNT 757
            |||||:|.||:|||||||||:||.|..:|    ..|.|||..||||.||..||.|:|||||.:..
Zfish   565 FVNYYSSCFYVAFFKGKFVGYPGNYAYMFGPWSGLRNEECEPGGCLIELTTQLVIVMVGKQVWGN 629

  Fly   758 ILEVYLPM---FWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQ 819
            |.|..:|.   :|         :||...|.|   ::...||.:|..|.:.|..|||.||||||:|
Zfish   630 IQEALVPWLRNWW---------VSRSARNHP---ESLYSRWEQDHDLQNLGQLGLFYEYLEMVIQ 682

  Fly   820 YGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVIT 884
            :||:|:|||:|||||..||:|||||:|:||.|..|..:|||:.:...||.|..||:.|...||:|
Zfish   683 FGFITLFVASFPLAPLLALMNNILEVRVDAWKFTTQFRRPVAAKAHSIGAWEEILNMIAVFSVVT 747

  Fly   885 NGFIIAFTSDMIPRLVYRHYVNKQG---TLDGYLNFTLSEFKVIDSPTLYSLAGD-------LSN 939
            |.||::|||||||||||: ||:..|   ::.||:..:||.:.:.:.|.......|       ..|
Zfish   748 NAFIVSFTSDMIPRLVYQ-YVHNTGNAASMSGYITHSLSIYNISEFPPENRPDDDENPDWFNAGN 811

  Fly   940 ITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQI 1004
            .|||||.|:|.||...::||.:..|:.|||.:|.|:::.|:.|.:|...|.|.|||:..:::.::
Zfish   812 YTTCRYRDYRYPPGHEKQYTHNMDFWHILAAKLAFIIIMEHVVFVVKFFVAWLIPDVPSDVKARV 876

  Fly  1005 RREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASIQEPNAKFINIEKL--LTENLT 1067
            :||.|:..|.:.|.|.     |:.|...| |.|.|..|:.|.:....:|    |.||  |::.||
Zfish   877 KRERYLIQEYLHDYEV-----EKLKNQLS-LNTDVHNDITACTCPTTDA----IPKLEVLSDCLT 931

Fly 1068 1067
Zfish 932 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	75/253 (30%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	245/614 (40%)
ano5a	XP_021326432.1	Anoct_dimer	78..285	CDD:318420	71/246 (29%)
ano5a	XP_021326432.1	Anoctamin	288..879	CDD:309610	245/614 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820