DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano2

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_017948300.2	Gene:	ano2 / 100492483	XenbaseID:	XB-GENE-981445	Length:	1089	Species:	Xenopus tropicalis

Alignment Length:	1046	Identity:	398/1046 - (38%)
Similarity:	566/1046 - (54%)	Gaps:	168/1046 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 SASRESLGAADKRARFAESNAPTLQLPESAEPRANG--KRPTGNRTNPSNPAAPLLPMTD--PDF 155
            |:|:.||      .:.....||...:|.:.....||  :|.||....|  |....|.:|.  |:.
Frog    38 SSSQISL------CKMEAPQAPATDIPLTVNAAQNGHIQRTTGESCPP--PKTKYLTVTQYLPEA 94

  Fly   156 V--KGNVGGVYDDRECSCPREF-----YQRGEINT---SLFFEDCVRSIDFVLAY---------- 200
            .  :|||.|.:|...|.....:     |..|...|   .:.|.|..|.:|:||||
Frog    95 YSHQGNVNGAFDASTCPDAHIYSVVNNYVDGNQQTKPSGMHFGDGKRKVDYVLAYHYRYRSSHHN 159

  Fly   201 ----------------------------------------------------------------- 200

Frog   160 GSPGSHRPPAVIVSNGNSITPEEVGKTPQQSLPGDLHHQGNQKKNIHNHQKHNNSDHSHSENGNQ 224

  Fly   201 ----------RINAHEPTELENTEKRRVFEANLISQGLEVE---SSQKDQIWFVKIHAPLEVLRR 252
                      .||.|:..|.|...:|..||.||:..|||:|   .::...:.||:||||..||.|
Frog   225 PHHPDGVVVVEINHHDALEEEKKIQREEFEQNLMEAGLELEKDPETKSQGLNFVRIHAPWPVLSR 289

  Fly   253 YAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRN 317
            .||.||:::|.|:.   ..:.:.:..|:..          .|:.|:.||.:...:..    |..|
Frog   290 EAEFLKIKVPTKKM---YEVKQDTGILKKL----------YSLWNKCTKILQPKVPQ----FSEN 337

  Fly   318 IYVDEEIFPKRAHRFTAIYSRDKEYLFDIR-QDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFG 381
            ..:....:|         :||||.:|:||: :|.||..|.|||||..||.|.. ..|.::.|  |
Frog   338 AKMKHLSYP---------FSRDKMHLYDIKDKDTFFDNATRSRIVHEILKRTS-SVKAKYSM--G 390

  Fly   382 IERLIAEGVYSAAYPLHDGEI----TETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLY 442
            |..|||..||.:|||||||:.    .||.. |.||::.||....:|:|||:|.|::|||.|||||
Frog   391 ITTLIANNVYDSAYPLHDGDYDHNKNETNE-RMLLHREWARYGAFYKYQPVDLIRKYFGEKIGLY 454

  Fly   443 FAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETC 506
            |||||.||::|:.||:||:|.|||...::...:|.:::|.. .....|||||| .|:||.|...|
Frog   455 FAWLGLYTWLLIPASLVGIIVFLYGCATIDADIPSQEMCDQ-EQGFVMCPLCDKACDFWKLSSAC 518

  Fly   507 NYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHE----EHPRPQYLA 567
            ..|:.::|.|||:||||:|||:.|||||||.|||....:::.|||||.:..|    |||||:|..
Frog   519 GTARASHLFDNPATVFFSVFMALWATLFLEYWKRLQMRLSYFWDLTGLEEEEERIKEHPRPEYET 583

  Fly   568 RLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKV 632
            :|..:.........|..:.....||.::||.:.:||.:|.:|||.|.|:..|::||::..|||.|
Frog   584 KLLLMKEKSKGNGKNGNKKEKLTWRDRIPAYLVNFSAILFMIALTFSAVFGVIIYRITTAAALAV 648

  Fly   633 GASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQF 697
            ..|.:|.|:..|..||:|..:||.::.||:.:|..:|::|||:|:.:|:..|::.|.||.:||:|
Frog   649 STSEVTRSNVRVTVTATAVIINLVVILILDEIYGSVAKWLTEIEVPKTEKTFEERLILKAFLLKF 713

  Fly   698 VNYYASIFYIAFFKGKFVGHPGEYNKLF-DYRQEECSSGGCLTELCIQLAIIMVGKQAF-NTILE 760
            ||.||||||:|||||:|.|.||.|..:| .||.|||:.||||.||||||:|||:|||.. |.:.|
Frog   714 VNSYASIFYVAFFKGRFTGRPGSYAYIFHGYRMEECAPGGCLIELCIQLSIIMLGKQLIQNNLFE 778

  Fly   761 VYLPMF---WRKVL--AIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQY 820
            :.:|.|   :||..  ..:.|.:.| |||..|     ::|:||:.|..:  .||.|||:||::|:
Frog   779 IAIPKFKKLYRKFKDERAEPGENNL-NNTKEP-----QQWVRDYALEPF--TGLTPEYMEMIIQF 835

  Fly   821 GFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITN 885
            ||||:|||:|||||.|||||||:|:||||||.:|..:||.:.|.:|||:||.||..|||.|||.|
Frog   836 GFVTLFVASFPLAPLFALLNNIIEVRLDAKKFVTELRRPDAVRAKDIGIWYNILSGIGKFSVIIN 900

  Fly   886 GFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKV--IDSPTLYSLAGDLSNITTCRYTDF 948
            .|:|:.|||.||||||::..::.||:.|:||.|||.|.|  :...|....:....|:..|||.|:
Frog   901 AFVISVTSDFIPRLVYQYMYSENGTMHGFLNHTLSYFNVSHLKPGTQPENSQFAQNVEICRYKDY 965

  Fly   949 RLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNE 1013
            |.|||||.:|..|..::.|||.||.||::|:|.|..:..:|.|.|||:..::.:||::|..:...
Frog   966 REPPSSPNQYDFSKQYWTILAVRLAFVILFQNLVMFLSAVVDWLIPDIPKDISEQIKKEKTMLVN 1030

  Fly  1014 IIIDQE 1019
            :.:.:|
Frog  1031 VFLKEE 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	90/334 (27%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	278/589 (47%)
ano2	XP_017948300.2	Anoct_dimer	235..440	CDD:406563	82/234 (35%)
ano2	XP_017948300.2	Anoctamin	443..1024	CDD:398306	278/589 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	544	1.000	Domainoid score	I260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	651	1.000	Inparanoid score	I783
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		otm49215
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060