DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano4

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_004912950.2	Gene:	ano4 / 100488512	XenbaseID:	XB-GENE-6039527	Length:	1157	Species:	Xenopus tropicalis

Alignment Length:	1102	Identity:	406/1102 - (36%)
Similarity:	588/1102 - (53%)	Gaps:	160/1102 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PPFSKDESFQLLERSPHNPAISPTTTVPLEPPFTTPLAPFDMELMKRHNLHERLTGKESF----W 79
            ||:..:|::...:.|.||..|              |..|....|:.:.:|...|:...|.    .
Frog   120 PPYVHNETYLPFDHSQHNAEI--------------PANPVSCSLLAQMDLSASLSCPTSLSVIPA 170

  Fly    80 RGRDTSQRFLDQE---------QLSASRESLGAADKRARFAESNAPTLQ----------LPESAE 125
            ..|.:||..|.|:         .:..|:..| ...::...|..:.|..|          |.::.:
Frog   171 VSRSSSQDTLSQDSDINQGISISIHGSKNQL-QIHQKGSVASHSLPNEQTVVGHSSLPPLRKAIK 234

  Fly   126 PRANGKRPTGN-RTNPSNPA------------APLLPMTDPDFV--KGNVGGVYDD-RECSCPRE 174
            ..|:||....| .|....|.            |...|..|.|.:  .||:..:.|: .......|
Frog   235 MEASGKCALSNGNTEIQYPGVKDINIFFDDLEAANSPSKDDDSLLHAGNLTSMSDEVSRLDAEGE 299

  Fly   175 FYQRGEIN--TSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVE---SSQ 234
            .....|.|  :.|||.|..|.||::|.||     .|.|: :|||.:||.|:.::||.:|   |..
Frog   300 VLSAPEKNKTSGLFFNDGKRRIDYILVYR-----KTSLQ-SEKREIFERNIRAEGLHLEKESSIV 358

  Fly   235 KDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNRS 299
            ...|.|||:|||.|||.||||::.:|||.:..:                :||..:...||.:.:.
Frog   359 NSDIIFVKLHAPWEVLGRYAELMNVRMPFRRKI----------------YYLHRRYKFMSRMEKQ 407

  Fly   300 TKSVFSSLKHVFQFFL--RNIYVDEEIFPKRAHR--FTAIYSRDKEYLFDI-RQDCFFTTAVRSR 359
            ...        |:..|  :.:.:|:|..|.....  :||.:|:.:.:.|.| .:|.||..|.|:|
Frog   408 LSR--------FRGLLPKKPMRLDKEKIPDLEENDCYTAPFSQQRIHHFIINNKDTFFNNATRTR 464

  Fly   360 IVEFILDRQRF-PAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTM--------RALLYKH 415
            ||..||.|.:: ..||:    .|:.||:....|.||:|||:|......::        |.||::.
Frog   465 IVHHILQRVKYEEGKNK----IGLNRLLTNCTYEAAFPLHEGSYRSKNSIKTHGAENHRHLLFEC 525

  Fly   416 WASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDI 480
            |||...||:|||||.::.|||.||||||||||:||.||..|:|||:..|||..|:|.:....::|
Frog   526 WASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAIVGLFVFLYGMFTLDSCQVSREI 590

  Fly   481 CQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAE 544
            ||:  |||||||||| :|.:..|.::|.|||||:|.||.:||||||||:.|||:|||.|||..|.
Frog   591 CQA--TNITMCPLCDKYCPYMRLSDSCIYAKVTHLFDNSATVFFAVFMAVWATVFLEFWKRRRAV 653

  Fly   545 ITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLI 609
            |.:.|||..::..||..|||:.|:  :....||:.::...||...| ..|....|.|.|.:..:|
Frog   654 IAYDWDLIDWEEEEEEIRPQFEAK--YSKKERVNPISGKPEPYQAF-ADKCSRLVVSASGIFFMI 715

  Fly   610 ALAFVALLAVVVYR---MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEY 671
            .:...|:..:|:||   :|..||.|..   :..:::.|..|.:|..:|.|::.:||.:|..:|.:
Frog   716 CVVIAAVFGIVIYRVVTVSTFAAFKWA---LIRNNSQVATTGTAVCINFCIIMLLNVLYERVALF 777

  Fly   672 LTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSG 735
            ||.||..||::::::|.|||::|.||||..:|.||||||.|:|.|.||.|.:|.: :|.|||...
Frog   778 LTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGRPGAYLRLINKWRLEECHPS 842

  Fly   736 GCLTELCIQLAIIMVGKQAFNTILEVYLPM---FW-RKVLAIQVGLSRLFNNTPNPDKAKDERWM 796
            |||.:||:|:.||||.||.:|..:|:..|:   :| |:.|..:.|   :...|..|      :|.
Frog   843 GCLIDLCLQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKLRQEHG---IHGKTALP------QWE 898

  Fly   797 RDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVS 861
            :|:.|......|||.|||||:||:||.|||||||||||..||||||:|:||||.|.:|..:||::
Frog   899 KDYNLQPINPYGLFEEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFITQWRRPLA 963

  Fly   862 QRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNK---QG-----TLDGYLNFT 918
            .|.:|||:||.||:.||.||||||.|:||.|||.||||||.:....   ||     .:.||:|.:
Frog   964 SRAKDIGIWYGILEGIGILSVITNAFVIAVTSDFIPRLVYAYKYGPCAGQGRAGEKCMVGYVNAS 1028

  Fly   919 LSEFKVIDSPTLYSLAGDLSN------------ITTCRYTDFRLPPSSPEKYTLSSMFYIILACR 971
            ||.|.|.|..       :.||            :..|||.|:|.|||:||.|..:..|:.:||.|
Frog  1029 LSVFLVTDFE-------NHSNSSRNGREFAEQYVKYCRYRDYRDPPSAPEPYAYTLQFWHVLAAR 1086

  Fly   972 LGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSS 1033
            |.|::|||:.|..:..|:.:.|||:..:|||::|||.|:..|::.:.|..|.:.|:.:|..:
Frog  1087 LAFIIVFEHLVFFIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERVQKEKKERKKN 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	85/258 (33%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	269/604 (45%)
ano4	XP_004912950.2	Anoct_dimer	313..538	CDD:406563	85/258 (33%)
ano4	XP_004912950.2	Anoctamin	541..1122	CDD:398306	269/604 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	651	1.000	Inparanoid score	I783
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		otm49215
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.090