Protein Alignment subdued and Ano2

DIOPT Version :10

• Sequence 1: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_017448527.2
• Gene: Ano2 / 100361584
• RGDID: 1591606
• Length: 975
• Species: Rattus norvegicus
• Alignment Length: 1030
• Identity: 380/1030 - (36%)
• Similarity: 553/1030 - (53%)
• Gaps: 174/1030 - (16%)

  Fly   130 GKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTS------LFFE 188
            |.|..|.|.|.|     |.|        ..|......|:.|....:....|..:|      :.|.
  Rat    19 GPRLPGQRDNSS-----LHP--------SQVSRRESSRDRSVINNYLDANEPASSEARLSRMHFH 70

  Fly   189 DCVRSIDFVLAY---RINAH-----------------------------------EPTELENTEK 215
            |..|.:|:||||   :..||                                   :..|.|..|:
  Rat    71 DNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDIELGPLDALEEERREQ 135

  Fly   216 RRVFEANLISQGLEVE---SSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMK---ESLCNLRISE 274
            |..||.||::.|||:|   .|:.....||:||||.:||.|.||.||:::|.|   |......|::
  Rat   136 RDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAK 200

  Fly   275 R-SNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSR 338
            : |..|:..:..|..::|..|  |...|::                    .:|         :||
  Rat   201 KFSAILQTLSSPLQPRVPEHS--NNRMKNL--------------------SYP---------FSR 234

  Fly   339 DKEYLFDIRQ-DCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEI 402
            :|.||::|:: |.||..|.|||||..||.|   .|.::.:...||..|||..:|.|||||||||.
  Rat   235 EKMYLYNIQEKDAFFDNATRSRIVHEILKR---TACSRANNTMGINSLIANNIYEAAYPLHDGEY 296

  Fly   403 TETG---TMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICF 464
            ...|   ..|.|||:.||....:|::||:|.|::|||.||||||||||.||..|:.:|::|||.|
  Rat   297 DSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVF 361

  Fly   465 LYSWFSLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMS 528
            ||...:::..:|.|::|...|. .||||||| .|::|:|...|..|:.::|.|||:||||::||:
  Rat   362 LYGCATIEEDIPSKEMCDHQNA-FTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMA 425

  Fly   529 FWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQY----------------LARLEHIPP--- 574
            .|||:|||.|||....:.:.|||||.:..|||.||:|                :.:||...|
  Rat   426 LWATMFLENWKRLQMRLGYFWDLTGIEEEEEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDD 490

  Fly   575 -TRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMT 638
             ...|.:|         |:.:.|..:.:...:|.:|||.|..:..|:|||::..|||.:..:  |
  Rat   491 EDDEDKLT---------WKDRFPGYLMNSVSILFMIALTFSIVFGVIVYRITTAAALSLNKA--T 544

  Fly   639 TSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYAS 703
            .|:..|..||:|..:||.::.||:.:|..:|::||::|:.:|:..|::.|.||.:||:|||.|:.
  Rat   545 RSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSP 609

  Fly   704 IFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAF-NTILEVYLPMF 766
            |||:|||||:|||.||.|..:|| ||.|||:.||||.||||||:|||:|||.. |.|.|:.:|.
  Rat   610 IFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPK- 673

  Fly   767 WRKVLAIQVGLSRLFN--------NTPNPDKAK-DERWMRDFKLLDWGARGLFPEYLEMVLQYGF 822
                      |.:||.        ...:||.:| .|:|..|:.|..:  .||.|||:||::|:||
  Rat   674 ----------LKKLFRKLKDETEPGESDPDHSKRPEQWDLDYSLEPY--TGLTPEYMEMIIQFGF 726

  Fly   823 VTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGF 887
            ||:|||:|||||.||||||::|:||||||.:|..:||.:.|.:|||:|:.||..|||.|||.|.|
  Rat   727 VTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAF 791

  Fly   888 IIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKV--IDSPTLYSLAGDLSNITTCRYTDFRL 950
            :||.|||.||||||::..:..|||.|::|.|||.|.|  :...|....:.....:..||:.|:|.
  Rat   792 VIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYRE 856

  Fly   951 PPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEII 1015
            ||.:|..|..|..::.:|:.||.||::|:|.|..:.:||.|.|||:..::.|||::|..:..:..
  Rat   857 PPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFF 921

  Fly  1016 IDQEAHRARF------------ERAKRSSSVLQTPVDQDMDAASIQEPNAKFINI 1058
            :.:|..:.:.            .|::||.:....|..:. ...||....::..|:
  Rat   922 LKEEHEKVKLADEPAQRSQGGGNRSRRSRAASSAPSGRS-QPGSIASSGSQHTNV 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	91/290 (31%)
		Anoctamin	431..1007	CDD:461349	265/609 (44%)
Ano2	XP_017448527.2	Anoct_dimer	68..325	CDD:465044	91/290 (31%)
		Anoctamin	328..913	CDD:461349	265/609 (44%)