DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and Ano2

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_008761521.2	Gene:	Ano2 / 100361584	RGDID:	1591606	Length:	979	Species:	Rattus norvegicus

Alignment Length:	1035	Identity:	379/1035 - (36%)
Similarity:	553/1035 - (53%)	Gaps:	180/1035 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 GKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTS------LFFE 188
            |.|..|.|.|.|     |.|        ..|......|:.|....:....|..:|      :.|.
  Rat    19 GPRLPGQRDNSS-----LHP--------SQVSRRESSRDRSVINNYLDANEPASSEARLSRMHFH 70

  Fly   189 DCVRSIDFVLAY---RINAH-----------------------------------EPTELENTEK 215
            |..|.:|:||||   :..||                                   :..|.|..|:
  Rat    71 DNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDIELGPLDALEEERREQ 135

  Fly   216 RRVFEANLISQGLEVE---SSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMK---ESLCNLRISE 274
            |..||.||::.|||:|   .|:.....||:||||.:||.|.||.||:::|.|   |......|::
  Rat   136 RDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAK 200

  Fly   275 R-SNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSR 338
            : |..|:..:..|..::|..|  |...|::                    .:|         :||
  Rat   201 KFSAILQTLSSPLQPRVPEHS--NNRMKNL--------------------SYP---------FSR 234

  Fly   339 DKEYLFDIRQ-DCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEI 402
            :|.||::|:: |.||..|.|||||..||.|   .|.::.:...||..|||..:|.|||||||||.
  Rat   235 EKMYLYNIQEKDAFFDNATRSRIVHEILKR---TACSRANNTMGINSLIANNIYEAAYPLHDGEY 296

  Fly   403 TETG---TMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICF 464
            ...|   ..|.|||:.||....:|::||:|.|::|||.||||||||||.||..|:.:|::|||.|
  Rat   297 DSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVF 361

  Fly   465 LYSWFSLKNYVPVKDICQSGNTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMS 528
            ||...:::..:|.|::|...|. .||||||| .|::|:|...|..|:.::|.|||:||||::||:
  Rat   362 LYGCATIEEDIPSKEMCDHQNA-FTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMA 425

  Fly   529 FWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVP---- 589
            .|||:|||.|||....:.:.|||||  :.||..|.|     ||   :|.:|.|.::|..:.
  Rat   426 LWATMFLENWKRLQMRLGYFWDLTG--IEEEEERSQ-----EH---SRPEYETKVREKLLKESGK 480

  Fly   590 ---------------------FWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVG 633
                                 .|:.:.|..:.:...:|.:|||.|..:..|:|||::..|||.:.
  Rat   481 SAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNSVSILFMIALTFSIVFGVIVYRITTAAALSLN 545

  Fly   634 ASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFV 698
            .:  |.|:..|..||:|..:||.::.||:.:|..:|::||::|:.:|:..|::.|.||.:||:||
  Rat   546 KA--TRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFV 608

  Fly   699 NYYASIFYIAFFKGKFVGHPGEYNKLFD-YRQEECSSGGCLTELCIQLAIIMVGKQAF-NTILEV 761
            |.|:.|||:|||||:|||.||.|..:|| ||.|||:.||||.||||||:|||:|||.. |.|.|:
  Rat   609 NAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEI 673

  Fly   762 YLPMFWRKVLAIQVGLSRLFN--------NTPNPDKAK-DERWMRDFKLLDWGARGLFPEYLEMV 817
            .:|.           |.:||.        ...:||.:| .|:|..|:.|..:  .||.|||:||:
  Rat   674 GVPK-----------LKKLFRKLKDETEPGESDPDHSKRPEQWDLDYSLEPY--TGLTPEYMEMI 725

  Fly   818 LQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSV 882
            :|:||||:|||:|||||.||||||::|:||||||.:|..:||.:.|.:|||:|:.||..|||.||
  Rat   726 IQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV 790

  Fly   883 ITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKV--IDSPTLYSLAGDLSNITTCRY 945
            |.|.|:||.|||.||||||::..:..|||.|::|.|||.|.|  :...|....:.....:..||:
  Rat   791 IINAFVIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRF 855

  Fly   946 TDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYV 1010
            .|:|.||.:|..|..|..::.:|:.||.||::|:|.|..:.:||.|.|||:..::.|||::|..:
  Rat   856 KDYREPPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSL 920

  Fly  1011 TNEIIIDQEAHRARF------------ERAKRSSSVLQTPVDQDMDAASIQEPNAKFINI 1058
            ..:..:.:|..:.:.            .|::||.:....|..:. ...||....::..|:
  Rat   921 LVDFFLKEEHEKVKLADEPAQRSQGGGNRSRRSRAASSAPSGRS-QPGSIASSGSQHTNV 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	91/290 (31%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	264/614 (43%)
Ano2	XP_008761521.2	Anoct_dimer	68..325	CDD:406563	91/290 (31%)
Ano2	XP_008761521.2	Anoctamin	328..917	CDD:398306	264/614 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	612	1.000	Inparanoid score	I874
OMA	1	1.010	-	-		QHG48769
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980