DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment subdued and ano11

DIOPT Version :9

Sequence 1:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	XP_009295190.1	Gene:	ano11 / 100007289	ZFINID:	ZDB-GENE-090313-245	Length:	893	Species:	Danio rerio

Alignment Length:	959	Identity:	360/959 - (37%)
Similarity:	525/959 - (54%)	Gaps:	141/959 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 ESAEPRANGKRPTGNRTNPS--NPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTS 184
            |:..|.:.|....|....|.  |.||.  ...||.:       |:.::..|.|..       :|.
Zfish    23 EAHAPDSYGSLQNGGFIPPRYLNTAAN--DDDDPIY-------VHCEQTASAPVH-------HTG 71

  Fly   185 LFFEDCVRSIDFVLAYRI----------------NAHEPTELENTEKRR---------VFEANLI 224
            .:|.|....|||||.:.:                .|.||.:.|:..:||         .|..||.
Zfish    72 NYFRDGQTKIDFVLVWEVKVRRKRRSRGQAEASEGAAEPAQEESRSERRKAQLARWRDKFILNLQ 136

  Fly   225 SQGL----EVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHY 285
            :.||    |..||.|..|.::|:|||.:||..|||.|.||.|::
Zfish   137 TAGLLMEKEESSSVKKTIHYLKLHAPWDVLVYYAEELCLRAPLQ--------------------- 180

  Fly   286 LTNKIPGMSVVNRSTKSVFSSLKHVFQ-FFLRNIYVDEEIFPKR-AHRFTAIYSRDKEYLF---D 345
                        ......|::...|.| .::.||..|.  .|.| ...:|..:.:.|...|   |
Zfish   181 ------------AQPHPDFNTSARVLQKLWVPNIMKDS--VPNRPVDYYTCAFRKSKMEKFLGSD 231

  Fly   346 IRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEI------TE 404
            .|:: :||:..|.|||..||.|..:..:.:.::  |:.||:.:|.::.|:|||:|..      |:
Zfish   232 DREN-YFTSTQRHRIVYEILARTAYGRRKRAEV--GVARLLRDGAFTGAFPLHEGPFKLPSCDTQ 293

  Fly   405 TGTM--RALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYS 467
            ...:  |.:||.:|||..||.:|||||.|:||||.||.|||||||:||..||.|::||...|:..
Zfish   294 PDQLNKRQVLYHYWASWLKWCKYQPLDHIREYFGEKIALYFAWLGFYTAWLLPAALVGTCVFVSG 358

  Fly   468 WFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWAT 532
            ..::.:..|.|:||:||...: |||||:.|..|::.:.|..|||.||.|:|.||||:||||.||.
Zfish   359 ILTMGSNTPAKEICESGGLYL-MCPLCETCKPWNMSDICPMAKVGYLFDHPGTVFFSVFMSLWAV 422

  Fly   533 LFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPA 597
            .|||.|||.:|.:.|.||...|...||.|||::.|.   .|....:.||.:|||..| .:.::..
Zfish   423 TFLEYWKRKNATLAHHWDCMDFHEDEEPPRPEFAAM---APAMEENPVTGVKEPYFP-EKARISR 483

  Fly   598 TVFSFSVVLLLIALAFVALLAVVVYRMSMLAAL--KVGASPMTTSSAIVLATASAAFVNLCLLYI 660
            .:....|:::::.:..:.|:.|::|| |:::.:  :.|:|.:.|.:..: |..|:..|||.|:.:
Zfish   484 MLTGSMVIVIMLCVVMIFLVTVIIYR-SIVSVMMFETGSSVLRTQAGNI-ANISSTLVNLALILL 546

  Fly   661 LNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLF 725
            :..:|..|||.||:.||.|||||::|:.|.|:::.||||:|:|.||:|||||:|||:||.|..||
Zfish   547 MGQVYTALAEQLTKWEMHRTQTQYEDAFTFKVFIFQFVNFYSSPFYVAFFKGRFVGYPGHYGTLF 611

  Fly   726 DYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMF--WRKVLAIQVGLSRLFNNTPNPD 788
            ..|.|:|..||||.||..||.|||||||..|.|.|..:|..  ||:        .|...:.....
Zfish   612 GMRNEDCGPGGCLIELAEQLCIIMVGKQLINNIQEFVIPKIKAWRQ--------KRALASVKKAQ 668

  Fly   789 KAKD-ERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKL 852
            |.:: |||.:|::|:.  ..|||.||||:|||:||:|||||||||||.||||||.:|:||||.|.
Zfish   669 KTQEPERWEQDYELIP--CEGLFDEYLEIVLQFGFITIFVAAFPLAPLFALLNNWVEVRLDAHKF 731

  Fly   853 LTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNF 917
            :..::|||::|.:.||||:.||:.:..:||:.|.|:||||||.:|||:|::..|..  |.||:||
Zfish   732 VCEYRRPVAERAQHIGVWFIILEALSHVSVVVNAFLIAFTSDFLPRLLYQYKFNND--LHGYVNF 794

  Fly   918 TLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFV 982
            ||:.     ||..|    :.|:.|.|||..||   ....||.|  :::.:||.||||::.||:.|
Zfish   795 TLAY-----SPPSY----NHSSHTVCRYKAFR---DENGKYKL--VYWELLAVRLGFIIAFEHVV 845

  Fly   983 ALVMILVRWCIPDMSVELRDQIRREVYVTNEIIID-QEAHRARFERAKR 1030
            ..|:.::.|.:||:...|:.:|:||.|:..:.:.| |||    ..:|||
Zfish   846 FFVLRVIDWMVPDIPESLQLKIKRERYLAKQALADNQEA----LLQAKR 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	78/283 (28%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	255/580 (44%)
ano11	XP_009295190.1	Anoct_dimer	73..319	CDD:292796	78/283 (28%)
ano11	XP_009295190.1	Anoctamin	322..871	CDD:282414	256/581 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820