DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	533	Identity:	134/533 - (25%)
Similarity:	239/533 - (44%)	Gaps:	32/533 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            |.|:.:|.:.|...|:|.:.:.|.....::::.|...|...:.:|.|.|......|::.....|:
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEV 65

  Fly    66 Y----AQFENPSCTR-------LDDING--HNVTVSSKAC-EKWIYNYDFGYRSMNTELNWVCDS 116
            :    .|.:..||.|       |..:||  .|.|.:::.| :.|||:......::.||.:.||..
Human    66 WLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSH 130

  Fly   117 AYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFIS 181
            ....::.|||:.:|.::|.:.:|.|:|::||...|||:............|..:...:...|.:|
Human   131 RALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195

  Fly   182 GLA-ADTNFYLMYIIVLEYI----RPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACT 241
            |:| |..:...|.:.| |::    |..:.||     :|..|.||......:|..|.||:......
Human   196 GMALAGISLNCMTLNV-EWMPIHTRACVGTL-----IGYVYSLGQFLLAGVAYAVPHWRHLQLLV 254

  Fly   242 SLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLG 306
            |.|.....:|.:...|||:|..:...:|..:..|:|||:.||.|...|..........:..|:..
Human   255 SAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTM 319

  Fly   307 GDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSS 371
            |  |.||:.:::.|.|.:|...|.|.......:..|..:..:::|.|:|.:::..:.....||:.
Human   320 G--KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAK 382

  Fly   372 VLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGS 436
            ::..|:.:.:||:.....:||:.|:.....|: |...|    :|:...|.:..:..:|.|:....
Human   383 LVGFLVINSLGRRPAQMAALLLAGICILLNGV-IPQDQ----SIVRTSLAVLGKGCLAASFNCIF 442

  Fly   437 QYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPET 501
            .|..||.||.:|..|:..........|.::|.:......:.:.|..|.|.:..|.|.|.:|||||
Human   443 LYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPET 507

  Fly   502 LNRSLPTTIEEGE 514
            |.:.||.|:::.|
Human   508 LGQPLPDTVQDLE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	129/516 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	93/378 (25%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	129/516 (25%)
		MFS	135..505	CDD:119392	94/382 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950