DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	126/539 - (23%)
Similarity:	237/539 - (43%)	Gaps:	38/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWC-YHDKLVNMTYKEIG- 63
            |.|:.:|.|.|.|..:|...|.|.....:::.||:.....::.||.|.| ......|::::::.
  Rat     1 MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWL 65

  Fly    64 EIYAQFEN----PSCTRL------------------DDINGHNVTVSSKACEK-WIYNYDFGYRS 105
            |.:...|.    .||.|.                  .:..|..:||   .|.: |.|:......:
  Rat    66 EAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTV---PCSQGWEYDRSEFSST 127

  Fly   106 MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKS 170
            :.||.:.||......:|..:.||||.:||.:.||.|||:.||...|:::..........:..:.:
  Rat   128 IATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASIN 192

  Fly   171 VATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQ 235
            ...|.:.|.::|.|......::..:.||::....||:. .:...:|:..|::....:..|:..|:
  Rat   193 YIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVA-GVISTVFWSGGVLLLALVGYLIRSWR 256

  Fly   236 IYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQM 300
            ..|...:||.:..::..:.|.|||:||:|:..::.|...|...||.||..|.:....:...:..:
  Rat   257 WLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEALNNVV 321

  Fly   301 THEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSAL 365
            |.|..    .::.:.||:|||.::|..:|........:...|..::.:|.|:|::.:....|...
  Rat   322 TMERA----LQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFGA 382

  Fly   366 AVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAI 430
            ..|||.:::..|..|:||: :....:|:|...|....:.::.:.   .:.:.|.:.:...|..|
  Rat   383 VELPSKIMVYFLVRRLGRR-LTEAGMLLGAALTFGTSLLVSLET---KSWITALVVVGKAFSEA- 442

  Fly   431 SYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVC 495
            ::.:...:.:||.||.:|..|:....:.|...:.|||....|...:...|.:..|.:....:...
  Rat   443 AFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTA 507

  Fly   496 LLLPETLNRSLPTTIEEGE 514
            ||||||....||.||::.|
  Rat   508 LLLPETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	119/522 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	85/373 (23%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	119/522 (23%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	86/376 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960