DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	144/576 - (25%)
Similarity:	237/576 - (41%)	Gaps:	84/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            |.|.:||.:.|....:|::.:.|.....:.::.|...|...:..|.|.|......::
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASI-------- 57

  Fly    66 YAQFENPSCTRLDDING-----------------HNVTVSSKAC-EKWIYNYDFGYRSMNT---E 109
                 .|....||. ||                 ::...:::.| :.||||     .:.:|   |
  Rat    58 -----GPWVLPLDP-NGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYN-----STRDTIVIE 111

  Fly   110 LNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATF 174
            .:.||.|.....:.||:|..|.:||....|.|||:.||.|.|..|.....|......|:.|:..:
  Rat   112 WDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVY 176

  Fly   175 TLCRF-----ISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHW 234
            .:.||     |||::..|     .|:.:|::..|||.:. :.::|..|.:|......||..:..|
  Rat   177 MIFRFLCGCSISGISLST-----VILNVEWVPTSMRAIS-STSIGYCYTIGQFILSGLAYAIPQW 235

  Fly   235 QIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQ 299
            :.....:|.|..:..|..:.|.||.:|||.......|:..|:|||.|||.:      :|.::
  Rat   236 RWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKK------EEGKK--- 291

  Fly   300 MTHEMLGGDDKKQAT-------LLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPF 357
            :|.|.|..:.:|..|       |.|:||...:|:.|..|..........|.:::..||..|::.:
  Rat   292 LTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIY 356

  Fly   358 IMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTI 422
            |:..:.....:|:..:.:|....:||:...|..||:.|    .|.:|:.:.. :...:|...|.:
  Rat   357 ILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAG----GAILALIFVP-SEMQLLRTALAV 416

  Fly   423 AARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVL 487
            ..:..::.|:.....|.:||.||.:|..|:...:|.....|.:||.:...|......|::|.|..
  Rat   417 FGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTT 481

  Fly   488 FFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESELEK 543
            ...|......|.|||||.||.|||            |....|.:....:.|||.||
  Rat   482 ALLGGSAAFFLLETLNRPLPETIE------------DIQNWHKQVQKTKQESEAEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	130/530 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	98/385 (25%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	130/530 (25%)
		MFS	124..492	CDD:119392	99/387 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536		5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347381
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950