DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	534	Identity:	108/534 - (20%)
Similarity:	211/534 - (39%)	Gaps:	88/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            ||.|:.....|:|...|..:.|....:.:.|:.......::..||::.
Frog     1 MDLDEAFLYIGEFGCCQKRLTAFLTLLQVYVACQSMLIVLVGAVPEYL----------------- 48

  Fly    66 YAQFENPSCTRLDDINGHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIG 130
                          |:..:::.|.:...|.:::.: .:.|:.:|.:.:.:.|||..:..||||.|
Frog    49 --------------IDNEDISASKEEYTKHLHDTN-NFTSIVSEWHLIKNEAYKVNLASSLFFAG 98

  Fly   131 SVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYII 195
            .::|.:.:|.||||:||.|..:...|......:.|....|...|.:.||..|:.......:.:::
Frog    99 LLIGNILFGPLSDKLGRRPVYLSGLFFDITFGYCTALAPSYEVFAVSRFFVGIMNGGMALVSFVL 163

  Fly   196 VLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQ 260
            ..||:..|...| ......|.:.:|:.|...|...:.:|:......:.|.:...|..|::.||.:
Frog   164 TQEYVGKSYWAL-TGSLTNLIFAVGIAFYALLGFYIRNWRTLAFVANSPGIFFFLLSFLLPESPR 227

  Fly   261 WLVTR----------------NDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDD 309
            ||.:.                |.::..:|:||                    .|.      |...
Frog   228 WLYSHGYTTEAEGVLQSMAVGNGVERPVVKLK--------------------SCP------GTSS 266

  Fly   310 KKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLL 374
            |...::.|:.:...:|..|::|.:...|.:|.|..::.|...:..:.::..:|..|..:|:..|.
Frog   267 KSAHSVFDLVKYGVLRWRTILLMYIWYVCSLVYYGLTLNAGELKGNLYLNVALYGLVEVPAFPLC 331

  Fly   375 VLLQDR--IGRKGMASGSLLVGGLFTAAAGIA----IAYQQHNHNAILLACLTIAARFGVAISYE 433
            :...::  .||:...:|       |...||.|    |...:.|.:.:....|.:..:..|:.::.
Frog   332 LYFIEKSWSGRRKATAG-------FLGFAGFACIFTIFLPETNGDLLNPTVLALFGKLSVSAAFN 389

  Fly   434 SGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLL 498
            ....|.:||.||.||..|:....:|......|:|:|..:.:...:.|.:..|:...:...:.|||
Frog   390 VVYIYTSELYPTVVRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVAFGISGISAGILSLLL 454

  Fly   499 PETLNRSLPTTIEE 512
            |||.|:.:..:||:
Frog   455 PETRNKPIAESIED 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	103/519 (20%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	83/395 (21%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	91/472 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920