DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and SLC22A4

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens

Alignment Length:	550	Identity:	134/550 - (24%)
Similarity:	251/550 - (45%)	Gaps:	43/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWC-----------YHDKLV 55
            |:|:::|..|::..:|.:|..|.....|....:..:...::..|:|.|           :.:..|
Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSV 67

  Fly    56 NMTYKEIGEI--------YAQFENPSCTRLDDINGHNV---TVSSKAC-EKWIYNYDFGYRSMNT 108
            .:..::..|:        .|...|.|...|:.  |.:|   .:..::| :.|.::.|....::.|
Human    68 PLRLRDGREVPHSCSRYRLATIANFSALGLEP--GRDVDLGQLEQESCLDGWEFSQDVYLSTVVT 130

  Fly   109 ELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVAT 173
            |.|.||:..:|..:..||||:|.::|:...|.|||:.||...|..:........|..||:.|...
Human   131 EWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEM 195

  Fly   174 FTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYL 238
            ||:...|.|:...:|:.:.:|:..|.:..|:|.:...:.|..|:.:|.:..|..|..:..|::.|
Human   196 FTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLL 260

  Fly   239 ACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHE 303
            ...::|.:|.|..::.:.||.:||:::.....|...:::.||.|...|....||..        |
Human   261 LALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV--------E 317

  Fly   304 MLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVL 368
            .|....:::|.:||:|||..:...|::.....|:.::.|.|:|.:...:....::...||||..:
Human   318 ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEI 382

  Fly   369 PSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLAC-LTIAARFGVAISY 432
            |:.:...||...:.|:.:.:..|..||      |:.:..|....:...|:. |.:..:||:..::
Human   383 PAYITAWLLLRTLPRRYIIAAVLFWGG------GVLLFIQLVPVDYYFLSIGLVMLGKFGITSAF 441

  Fly   433 ESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLL 497
            .....:..||.||.||...|.....|....|.:|||.::||.:.:..|.|::|.|......:.|.
Human   442 SMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLF 506

  Fly   498 LPETLNRSLPTTIEEGEV---FGKGERMFD 524
            .||:|..:||.|:|:.:.   |..|::..|
Human   507 FPESLGMTLPETLEQMQKVKWFRSGKKTRD 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	126/521 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	96/374 (26%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	126/521 (24%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	102/398 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950