Protein Alignment CG6231 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_001262734.1
• Gene: CG6231 / 42339
• FlyBaseID: FBgn0038720
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 160/619 - (25%)
• Similarity: 270/619 - (43%)
• Gaps: 113/619 - (18%)

  Fly     3 FDQILAKCGDFNRYQ---FMILALFG--FINIIVSMHYF-TQTVISFVPDH-WCYHDKLVNMTYK 60
            ||:.|.:.|:|.|:|   |::|.|.|  |..:.|.:.:. ||      ||| ||.......:..:
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQ------PDHYWCRGPSAAALAER 62

  Fly    61 -------EIGEIYAQFENPS-------CTR--LDDINGHNVTVSSKACEKWI------------- 96
                   |..........|.       |.|  |:..|......|:.:|...:
Human    63 CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPC 127

  Fly    97 ---YNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCG 158
               :.|...:.::.:|.:.||.:|:...:.|::..:|.:.|....|..:|:.||:...:||  |.
Human   128 RGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLS--CL 190

  Fly   159 FAGDFSTI--FTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGL 221
            ..|....:  |..:...|.:.||:.|:.....:...|:||.|.:....|.: :.:.:.:|:.||:
Human   191 GVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI-VGIVIQMFFTLGI 254

  Fly   222 VFTPWLAVLVGHWQ-IYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCR 285
            :..|.:|..:.:|| |.||.| ||..|.:|||:||.||.:||:||...|.|:..|:|:||.||..
Human   255 IILPGIAYFIPNWQGIQLAIT-LPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKY 318

  Fly   286 VSQADFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVE 350
            :| :::.|.    .:|.|     :....:.||:.|||:|||.||||.|......:.|..:...:.
Human   319 LS-SNYSEI----TVTDE-----EVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLG 373

  Fly   351 GMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGG---LFTAAAGIAIAYQQHNH 412
            .:|.:.:|.|.:|.:..||.::|::|..:|:||:...:.|.:|.|   |.||.....||:
Human   374 IIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAW----- 433

  Fly   413 NAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILW-LGTFF 476
               |...:....|.|:.:::|......:||.||.:|..||:...........:||::|: |...:
Human   434 ---LRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVW 495

  Fly   477 KAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESEL 541
            ...|.||.|:|......:.:|||||...:||.|::                            ::
Human   496 LELPLIIFGILASICGGLVMLLPETKGIALPETVD----------------------------DV 532

  Fly   542 EKYKRKHSLIDAKQMQMESCSNGKRKQSLIDADH 575
            ||....|           ||..|:.|::.:...|
Human   533 EKLGSPH-----------SCKCGRNKKTPVSRSH 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	148/543 (27%)
		MFS	125..499	CDD:119392	111/380 (29%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	148/543 (27%)
		MFS	149..518	CDD:119392	113/390 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950