Protein Alignment CG6231 and SLC22A15

DIOPT Version :9

• Sequence 1: NP_001262734.1
• Gene: CG6231 / 42339
• FlyBaseID: FBgn0038720
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_060890.2
• Gene: SLC22A15 / 55356
• HGNCID: 20301
• Length: 547
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 152/623 - (24%)
• Similarity: 247/623 - (39%)
• Gaps: 118/623 - (18%)

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTV----ISFVPD-HWCYHDKLVNMTY- 59
            |:.::.....|:...||..:..|   :.:::.::..|:.:    :...|. ||...:.|.|.::
Human     1 MEVEEAFQAVGEMGIYQMYLCFL---LAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHG 62

  Fly    60 -KEIGEIYAQFENPSCTRLDDINGHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIG 123
             :..||..|            .....:|.:.....|.:: :...:.|:.:|...:.:.:||....
Human    63 NQSAGEDQA------------FGDWLLTANGSEIHKHVH-FSSSFTSIASEWFLIANRSYKVSAA 114

  Fly   124 QSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGD----FSTIFTKSVATFTLCRFISGLA 184
            .|.||.|..||.:.:|.|||:.||....:    .|||.|    .:..|:.|...|.:.||:.|:.
Human   115 SSFFFSGVFVGVISFGQLSDRFGRKKVYL----TGFALDILFAIANGFSPSYEFFAVTRFLVGMM 175

  Fly   185 ADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVV 249
            ......:.::::.|.:..:...|..::. |||:.:|:.....|...:..|:......:|...:|.
Human   176 NGGMSLVAFVLLNECVGTAYWALAGSIG-GLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVF 239

  Fly   250 LYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFD---EFRRHCQMTHEMLGGDDKK 311
            |....:.||.:||.::..:..|...|..:||.|  |..:..|.   ...|.|:.|
Human   240 LLSLFIPESPRWLYSQGRLSEAEEALYLIAKRN--RKLKCTFSLTHPANRSCRET---------- 292

  Fly   312 QATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVL 376
             .:.||:||...:..:||||.|...|.:|.|..::.:...:|.|.:...:||.|..:||..|.:.
Human   293 -GSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIY 356

  Fly   377 L--QDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQ----------HNHNAILLACLTIAARFGVA 429
            |  |...|||...|..|.:|||   |..|.:...:          ::|:..||..|||:|.|.:.
Human   357 LINQKWFGRKRTLSAFLCLGGL---ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIV 418

  Fly   430 ISYESGSQYATELIPTCVRGQGVAAV----HVAGFAASFL--APYILWLGTFFKAAPSIILGVLF 488
            ..|.|      ||.||.:|..|:...    .|.|..|.|:  ..|:.|      :.|.|:.|...
Human   419 YIYTS------ELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQW------SLPFIVFGATG 471

  Fly   489 FAGSFVCLLLPETLNRSLPTTIEEGEVFG---KGERMFDFPCLHNKH--DDE-----ESESELEK 543
            .....:.||||||||..|..|..:.:|:.   .||.......|..:.  |.|     |||.|.|.
Human   472 LTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEF 536

  Fly   544 YKRKHSLIDAKQMQMESCSNGKRKQSLIDADHEEQALK 581
            |                           |||.|.|.:|
Human   537 Y---------------------------DADEETQMIK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	132/529 (25%)
		MFS	125..499	CDD:119392	106/398 (27%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	103/390 (26%)
		MFS_1	111..450	CDD:284993	97/365 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..547		12/51 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850