DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and Slc22a28

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001013842.2	Gene:	Slc22a28 / 434674	MGIID:	3645714	Length:	552	Species:	Mus musculus

Alignment Length:	556	Identity:	136/556 - (24%)
Similarity:	239/556 - (42%)	Gaps:	71/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFM----ILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKE 61
            |.|.::|.:.|...|:|.:    :|.|.|.:...::|..||    :.:|:|.|:...|.|.|..:
Mouse     1 MAFQELLNQVGSLGRFQILQISFVLFLVGLVVPHITMENFT----AAIPNHRCWAPILDNDTASD 61

  Fly    62 IGE--------------IYAQFENPSCTRLDDINGH----NVTVSSKA------C-EKWIYNYDF 101
            .|.              :.:......|.|......|    |.|.|::.      | :.|:|:...
Mouse    62 NGSRILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNETEPDTEPCVDGWVYDRSN 126

  Fly   102 GYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCG---FA-GD 162
            ...::.||.:.||:|.....:.:..|.||..:|.:..|.|||:.||  ..||:  |.   || .:
Mouse   127 FLSTIVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGR--KFILT--CALLQFAITE 187

  Fly   163 FSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYC---LGLVFT 224
            ....|..|...:.|.||::|::.:.......:::||:..|..    |.|...|..|   :|.:..
Mouse   188 TCVAFAPSFFIYCLLRFLAGMSVEPISVNSNLLILEWTNPKF----LGMVAVLTSCAASIGYMIL 248

  Fly   225 PWLAVLVGHWQIYLACTSLPILLVVLYYFV----VQESAQWLVTRNDIDGAIVRLKRVAKFNGCR 285
            ..||.|...|.......|:||    .::|:    :.|||:||:..|.....:..|::||..||.:
Mouse   249 AGLAFLFRIWHHLQLAMSVPI----FFFFILTRWMSESARWLIVTNKPQKGLKELRKVAHMNGMK 309

  Fly   286 VSQADFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVE 350
            .|............|.:|:...  |::::..|:|.||.:|....:|.|...:.|:....:|.:::
Mouse   310 NSGNTLTMEVVEASMKNELEAA--KRKSSPRDLFHTPILRNRICVLSFMRYLFTVSIFGLSLHLQ 372

  Fly   351 GMGISPFIM-FSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNA 414
            .:..:..:: |..|||.:| .||:...:.:.:||:......:.:.|:|...|    .:.......
Mouse   373 HLSTNIILLRFLSSALGIL-ISVIGHFVLNHMGRRITQLVLMSLRGIFMLTA----VFVPQEMQT 432

  Fly   415 ILLACLTIAARFG---VAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFF 476
            :.:..:|:||...   :.:|    :.:..||:||.:|..|:..:.:.|.:..||||..:.|.|:.
Mouse   433 LRIIVVTLAAALSSLCMCVS----NLHINELLPTTLRATGMGVIGMFGNSGLFLAPLFMLLATYS 493

  Fly   477 KAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEE 512
            ...|.|..|.......|...|||||.|:.||.:|.:
Mouse   494 ANLPWIFYGGFSILYGFSVFLLPETKNQPLPDSIHD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	132/541 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	95/388 (24%)
Slc22a28	NP_001013842.2	2A0119	11..525	CDD:273328	131/540 (24%)
Slc22a28	NP_001013842.2	MFS	151..516	CDD:119392	95/387 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940