DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Orct

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	162/553 - (29%)
Similarity:	262/553 - (47%)	Gaps:	65/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            |.:|.::...|:|..||..|..|.....|:.:.|......:...||..|      .:.| |.|.|
  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRC------ALPY-ENGSI 58

  Fly    66 Y---------AQFENPSCTRLD------DINGHNVTVSS---KACEKWIYNYDFGYRSMNTELNW 112
            |         :..||..|:..|      .:|| ::..||   |.|..::|:......|..||.|.
  Fly    59 YELSPHLWNLSYPENERCSYYDVDYTEEYLNG-SIPRSSNETKTCSSYVYDRSKYLNSAVTEWNL 122

  Fly   113 VCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVP----ALILSNFCGFAGDFSTIFTKSVA- 172
            ||..:..:....|||.:|.::|:|.:|.:|||:||.|    :|:|....|...        :||
  Fly   123 VCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLA--------AVAP 179

  Fly   173 ---TFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHW 234
               ::|:.|.|.|......|.:.|:|.||.:..|.| |...:|:.:|:.:|.:.|...|..:..|
  Fly   180 EYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVAMQMFFSVGFMLTAGFAYFIHDW 243

  Fly   235 QIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQ 299
            :......:||.||.:.||:::.|||:||:.:...|.|.|.:::.||.|...|....::      |
  Fly   244 RWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYE------Q 302

  Fly   300 MTHEMLGGDDKKQ---------ATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGIS 355
            :..|:  .:.|||         ||:.|:.|.|.:|:.||::||...|.:..|..:|.|...:|.:
  Fly   303 LVDEV--AEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGN 365

  Fly   356 PFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACL 420
            ..:.|.:|....:|...||:...:|.||:.:..|:::|.|:    :.:|..:...:.|.:::||.
  Fly   366 QLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGI----SLLATIFVPSDMNWLIVACA 426

  Fly   421 TIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILG 485
            .| .:..:..||.:...::.|..||.||..|:.|..:.......||||:..||..::..|.||.|
  Fly   427 MI-GKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICG 490

  Fly   486 VLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGK 518
            .|......:.||||||||:.:|.|||:||.|||
  Fly   491 ALSLTAGLLSLLLPETLNKPMPETIEDGENFGK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	152/532 (29%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	112/390 (29%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	152/532 (29%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	108/377 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458405
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990