DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Orct2

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	154/550 - (28%)
Similarity:	256/550 - (46%)	Gaps:	53/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWC--------YHD---KL 54
            |.:|:.:...|||.|||.:|..|....:|.|:.|......:...||..|        .:|   .|
  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65

  Fly    55 VNMTYKEIGEIYAQFENPSCTRLD------DINGHNVTVSS---KACEKWIYNYDFGYRSMNTEL 110
            .|::|.         ||..|:..|      .:|| ::..||   |.|..::|:......|..||.
  Fly    66 WNLSYP---------ENERCSYYDVDYTEEYLNG-SIPRSSNETKTCSSYVYDRSKYLNSAVTEW 120

  Fly   111 NWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILS-----NFCGFAGDFSTIFTKS 170
            |.||...:.|....|||.:|.::|::.:|.||||.||.|.|..|     .|...||.....|
  Fly   121 NLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYF--- 182

  Fly   171 VATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQ 235
              |:|..|.:.|......|.:.|::.:|.:.|..| |...:.|.:|:.:|.:.|...|..|..|:
  Fly   183 --TYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLTAVFAYFVHDWR 244

  Fly   236 IYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQM 300
            ......:||.|:.:.||:::.|||:||:.:...|.||..:::.|:||...:|.....|.....:.
  Fly   245 WLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGEN 309

  Fly   301 THEMLGG-------DDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFI 358
            :.|....       |:....::.|:|..|.:|:.||::|...:|.:..|..:|.|...:|.:..:
  Fly   310 SEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLL 374

  Fly   359 MFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIA 423
            .|.:|....:|:.:.|:|..:|.||:.:..|.|::.|| :..|.:.|..:.|   .:::|| .:.
  Fly   375 NFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGL-SLLATVIIPQRMH---TLIVAC-AML 434

  Fly   424 ARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLF 488
            .:..:..||.:...::.|..||.||...:.|..:....:..:||::.:|.|.:|..|.:|.|.|.
  Fly   435 GKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLT 499

  Fly   489 FAGSFVCLLLPETLNRSLPTTIEEGEVFGK 518
            .....:.||||||.|:.:..||.:||.|||
  Fly   500 LVAGLLSLLLPETHNKPMLETIADGERFGK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	145/529 (27%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	104/385 (27%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	145/529 (27%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	103/386 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458393
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990