DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and CG17752

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_650817.1	Gene:	CG17752 / 42337	FlyBaseID:	FBgn0038718	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	250/546 - (45%)
Similarity:	361/546 - (66%)	Gaps:	19/546 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            ||..::|.|||:|..||.::|.|:|:.||:.|:|||:||:|||.|.|.|      :...:|..:.
  Fly     1 MDLQRVLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLISFTPSHRC------SAPVEEFSQN 59

  Fly    66 YAQFENPSCTRLDDINGHNVTVSS---KACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLF 127
            :.  |..||:.:.    ::|.::|   ..|..|.::.:..|.|:.|||.||||.|||..:|||.|
  Fly    60 FT--ELLSCSVIQ----YDVDMTSFRDNKCSSWDFDKESNYESITTELEWVCDDAYKLAVGQSFF 118

  Fly   128 FIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLM 192
            ||||.:|::|:|.|:|:|||:||.:||...|.:|||.|.|..|:..|:..||||||:.||.:.||
  Fly   119 FIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPMFSFTRFISGLSMDTQYVLM 183

  Fly   193 YIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQE 257
            ||:|.||:.|..||.|||:.:|:||.:||:.:||:|:.:|:|:.||...|||.|.::::...:.|
  Fly   184 YILVFEYLSPQHRTFGLNIILGVFYSIGLMISPWIAIWLGNWRSYLWAASLPALGMLIFPLFLHE 248

  Fly   258 SAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDDKKQA-TLLDMFRT 321
            |.:||:|:...|.|:..||.||||||.:|..:.||||.:|.:   |.|....||.: |.:.|.||
  Fly   249 SVEWLLTKGKFDKAVNNLKSVAKFNGRQVEDSVFDEFIKHYR---EKLNSAQKKSSDTFMGMLRT 310

  Fly   322 PRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGM 386
            ||:||.|:||..|||:||:.:|.:||||||:|||||.:||.|...|||..:.::|.|::||||||
  Fly   311 PRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFVVLPGGLSIILFQNKIGRKGM 375

  Fly   387 ASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQG 451
            |..|||||...||..|..:......:.::||..:...||||..::|::.:|||.|:|||.|||:|
  Fly   376 ACASLLVGAFITATTGYLVGTLDPANYSVLLGFMVCLARFGAVVAYDAEAQYAAEIIPTSVRGRG 440

  Fly   452 VAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVF 516
            ||.:||.|.|.:|.:.||::||||:|..||:::..|...|:.:||.|||||::.||.|:||||:|
  Fly   441 VANIHVVGNAFAFFSSYIIYLGTFYKPLPSLLISFLLIIGACLCLTLPETLHKQLPQTLEEGEIF 505

  Fly   517 GKGERMFDFPCLHNKHDDEESESELE 542
            .|||:.:.|||...|....:|||:||
  Fly   506 AKGEKWYFFPCFSRKRQSNKSESQLE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	227/501 (45%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	177/374 (47%)
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	227/501 (45%)
CG17752	NP_650817.1	MFS	116..488	CDD:119392	177/374 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471376
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	9	8.900