DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and CG17751

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	238/551 - (43%)
Similarity:	352/551 - (63%)	Gaps:	36/551 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            ||...:|.|||:|..||.::|.|||:.||:.|:|||:||:|||.|.|
  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSH------------------ 47

  Fly    66 YAQFENPSCTRLDDINGHNVTVSSKA---------CEKWIYNYDFGYRSMNTELNWVCDSAYKAR 121
                   .|:|.:|...::.::.|.:         |..|.:..:..|.|:.|||.||||.|||..
  Fly    48 -------RCSRPEDYQPNSTSLLSCSVMQFDKEFKCTSWDFERESNYESITTELEWVCDDAYKLA 105

  Fly   122 IGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAAD 186
            :|||.|||||.:|::|:|.|:|:|||:||.:||...|.:|||.|.|..|:..|:..||||||..|
  Fly   106 VGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPWFSFTRFISGLFMD 170

  Fly   187 TNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLY 251
            |.:.||||:|.||:.|..||.|||:.:|:|||:||:.:||:|:.|.:|:.||...|||.|.::|:
  Fly   171 TQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLF 235

  Fly   252 YFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDDKKQATLL 316
            ...:.|||:||:|:...:.|...|:.||||||.:|..:.||||.:|.:  .::....:|...|.:
  Fly   236 PVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDSVFDEFIKHYR--EKLNNSQNKSSDTFM 298

  Fly   317 DMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRI 381
            .|.||||:||.|:||..|||:||:.:|.:||||||:|||||.:||.|....||:.:.::|.|::|
  Fly   299 GMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCYLPAGLTIILFQNKI 363

  Fly   382 GRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTC 446
            ||||||..||.||.:.|||.|..:|....:..::||..:....|:|..::|::.:|||.|:|||.
  Fly   364 GRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAEIIPTS 428

  Fly   447 VRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIE 511
            |:|:|||.:||.|.|.:|.:.||::||||:|..||:::..:...|:.:||.|||||:::||..:|
  Fly   429 VKGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLMISFILLIGACLCLALPETLHKNLPQNLE 493

  Fly   512 EGEVFGKGERMFDFPCLHNKHDDEESESELE 542
            |||:|.|||:.:.|||...:...::|.::||
  Fly   494 EGEMFAKGEKWYFFPCFSRRPKTQKSATQLE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	219/506 (43%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	171/373 (46%)
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	218/505 (43%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	171/373 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.860