DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and slc22a2

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	587	Identity:	153/587 - (26%)
Similarity:	262/587 - (44%)	Gaps:	91/587 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHD--------------- 52
            |::||.:.|.|.|.|..|...|..::|..|..|.......|.|:|||...
Zfish     4 FEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWSLQD 68

  Fly    53 ------KLVN----MTYKEIGEIYAQF-------ENPSCTRLDDINGHNVTV-SSKAC-EKWIYN 98
                  .|:|    .:|.:.|.....:       |||.    .|.|...::| ...:| :.|.|:
Zfish    69 ARRATVPLINGSSGASYSQCGRFDVDWNATGLSCENPD----GDFNQSQLSVMPMMSCVDGWEYD 129

  Fly    99 YDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDF 163
            | .|.:|..||.:.||..|:...:.|:...||.:||::..|.|:||.||:.:.:::||  |.|..
Zfish   130 Y-VGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNF--FIGVT 191

  Fly   164 STIFTKSVATFTLC--RFISGLAADTNFYLMYIIVLEYIR-PSMRTLGLNMAVGLFYCLGLVFTP 225
            ..:...|....:|.  |.:.|......:.:.|:::.|.:. ...||:|:...  ||:.:|::..|
Zfish   192 GILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQ--LFFSMGILLLP 254

  Fly   226 WLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQAD 290
            .||..:.:|:......::|.:..:.||:.:.||.:||:|:|.|..|:...|.:||.|
Zfish   255 LLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKEN-------- 311

  Fly   291 FDEFRRHCQMTHEMLGGDD---KKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGM 352
                |:......|.|..|:   ...|:.:|:|:|.::|..|.||.|......:.|..:...:..:
Zfish   312 ----RKTLSKKIETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGIL 372

  Fly   353 GISPFIMFSLSALAVLPSSVLLVLLQDRIGRK-GMASGSLLVGG--LFTAAAGIAIAYQQHNHNA 414
            |.:.::.|.:|.:..||::.|::|..:||||: ..|:.:::.|.  |.||....::.:
Zfish   373 GGNVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDSMFW------- 430

  Fly   415 ILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILW-LGTFFKA 478
             |.:.:....|.|:.:::|......|||.||.:|..||:...........:||::|: |...:..
Zfish   431 -LKSAVACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLE 494

  Fly   479 APSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLH---NKHDDEESESE 540
            .|.||.|.|.|....:.||||||....||.||::.|              |   ||.:.::|: :
Zfish   495 LPLIIFGALAFVAGGLVLLLPETKGVPLPETIDDIE--------------HPNRNKENPQQSQ-Q 544

  Fly   541 LE 542
            ||
Zfish   545 LE 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	141/541 (26%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	99/383 (26%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	141/541 (26%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	101/392 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588922
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950