DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	543	Identity:	134/543 - (24%)
Similarity:	237/543 - (43%)	Gaps:	48/543 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            |.|..:|.:.|...|:|.:.:.|.....::::.|...|..::.||.|.|.....::|:..:..::
Zfish     1 MAFSDLLEQVGSTGRFQVLHVTLLSMPILMMASHNLLQNFVAAVPPHHCQPHANLSMSSTDAMDV 65

  Fly    66 Y---------AQFENPSCTRLD----DINGHNVTVS----------SKACEK-WIYNYDFGYRSM 106
            .         .:.|.  |.|..    .|...|.:.|          :::||. |.||......::
Zfish    66 LRATVPLGLNGKLER--CKRYTTPQWQILSLNTSESLWDESMAETETQSCEDGWFYNMTEMSSTI 128

  Fly   107 NTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSV 171
            .||.:.|||.....::.|:.:..|.:||.:.:|.|||:.||...|::||.....|.....|:.|.
Zfish   129 ITEWDLVCDYRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIGGTCVAFSTSF 193

  Fly   172 ATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQI 236
            ..|.:.|...|:|........:.:::|:|...:||: :....|..|..|.:....:|..:..|:.
Zfish   194 TMFCVFRVCCGMALSGLVLNSFSLIVEWIPTRVRTV-VGTGTGYCYTTGQLILAAVAYCIRDWRW 257

  Fly   237 YLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMT 301
            .....|||..:..||.:...|||:|||.....:.|:..||.||:.|| |.::.|        ::.
Zfish   258 LTLAVSLPFYVSFLYSWWFLESARWLVLTKKPEQAVKNLKTVARING-RSAEGD--------KID 313

  Fly   302 HEMLGGDDKKQA-------TLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIM 359
            .|||....||:.       :.||:.||..||..|:.|.......:..|..:|.:::..|:|.:::
Zfish   314 LEMLQESMKKEMACSKGSYSALDLLRTSTMRTITICLSAVWFSTSFAYYGLSMDLQKFGVSIYLI 378

  Fly   360 FSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAA 424
            ..:.....:|:.:::.:....:||:....|:|::.|:.     |.|.....:...:|...|.:..
Zfish   379 QIIFGAVDIPAKIIVTICMSMLGRRPSQCGALVLAGIM-----ILINLLVPSDLQMLRTSLAVIG 438

  Fly   425 RFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFF 489
            :..:|.|:.....||.||.||.:|..|:..|.:.....:.:||.:|.||..:...|..|.|....
Zfish   439 KGCLAASFNCCYLYAGELYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYPWIPGFIYGGAPI 503

  Fly   490 AGSFVCLLLPETLNRSLPTTIEE 512
            ........|||||::.||.||::
Zfish   504 VSGIFAFFLPETLSQPLPDTIQD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	129/528 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	94/380 (25%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	129/528 (24%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	103/411 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950