DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and CG7458

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	131/564 - (23%)
Similarity:	238/564 - (42%)	Gaps:	82/564 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQILAKCGDFNRYQ---FMILALFGFINIIVSMHY-FT-QTVISFVPDHWC-----------YHD 52
            |.||.:.|.|.|||   :::|.:....|...|:.| || .||:     |.|           |.:
  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVV-----HRCTVPQCDSPSSVYEE 98

  Fly    53 KLVNMTYKEIGEIYAQFENPSCTRLDDINGHN-----------VTVSSKACEKWIYNYDFGYR-- 104
            ..:..|..:....:......:....|.|:|:.           .|::|:.|.:     ||.:|
  Fly    99 DWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGR-----DFKFRDE 158

  Fly   105 --SMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTI- 166
              :::||....|:..:|..:..::..:|..||....|..:|:.||...|.:      ||..|.:
  Fly   159 EKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAV------AGSVSALM 217

  Fly   167 -----FTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPW 226
                 .:.:.:.|.:..|:......|.|...:::.:|.:.|..|.....: :.:||.||..|..:
  Fly   218 GVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGF 281

  Fly   227 LAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADF 291
            ||..|.||:..|.....|.:|.:|:.:::.||.:||:::...:.|...|:|.|     |::|...
  Fly   282 LASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAA-----RINQRPL 341

  Fly   292 DEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYD---------AVSR 347
            .|     :..:::|..:.:|.:...:. :.|.||   .::||...:...|..         .:|.
  Fly   342 PE-----EQLNDLLTSNRQKLSQANES-QYPIMR---AVVFFSLRIANCCLCWFTHTLIALGLSL 397

  Fly   348 NVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNH 412
            |...:|.:.:..|.|:....:|..:|.:::.||:||:.....|:|   |.....|.:.|....|:
  Fly   398 NSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASML---LCAICMGASAAVPADNY 459

  Fly   413 NAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFK 477
            ...|  .|.:..:..:..|::....:.:|:.||.||...::...:.|...|.|||....|..::.
  Fly   460 AGSL--ALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYI 522

  Fly   478 AAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGER 521
            .||.|:.........|:.|..|||.::.|||||||.....:.:|
  Fly   523 YAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKR 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	122/543 (22%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	87/388 (22%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	122/543 (22%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	91/408 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458490
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990