DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and SLC22A25

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	583	Identity:	133/583 - (22%)
Similarity:	237/583 - (40%)	Gaps:	91/583 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKE---- 61
            |.|..:|.:.|...|:|.:.:......|:||......:...:|:.||.|:...|.|.|..:
Human     1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPG 65

  Fly    62 ------IGEIYAQFEN----PSCTR-------LDDINGHNVTVS---SKAC-EKWIYNYDFGYRS 105
                  :..|...|::    ..|.|       |..:||.....|   ::.| :.|:|:......:
Human    66 TLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPST 130

  Fly   106 MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIG---------------RVPALILSN 155
            :.|:.:.||:|.....:.:.||..|.:||...||.|||:..               .||..|..:
Human   131 IVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPIAIHQH 195

  Fly   156 FCGFAG---------------DFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMR 205
            ...:.|               .....|..::..:...||::|.|..:......::::|:|....
Human   196 HVFWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQF- 259

  Fly   206 TLGLNMAVGLFYC---LGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRND 267
               ..||:.|..|   :|.:....||.::....|.....|.|..:..|:...:.|||:||:..|.
Human   260 ---CAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNK 321

  Fly   268 IDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDDK-------KQATLLDMFRTPRMR 325
            .:..:..|::.|..||.:.:: |.        :|.|:|....|       |:.:|.::.|.|.:.
Human   322 PEEGLKELRKAAHRNGMKNAE-DI--------LTMEVLKSTMKQELEAAQKKHSLCELLRIPNIC 377

  Fly   326 KNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGS 390
            |....|.|.....|:.:..::.:::.:|.:.|::.:|.....|.::.:.....:.:.|:  .|..
Human   378 KRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRR--LSQM 440

  Fly   391 LLVGGLFTAAAGIAIAYQQHNHNAILLACLTI-AARFGVAISYESGSQYATELIPTCVRGQGVAA 454
            ||:..|.|....|....|:.....::||.|.: ||..|:..|    :....||||:.:||:   |
Human   441 LLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCS----TAQENELIPSIIRGR---A 498

  Fly   455 VHVAGFAASF---LAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGE 514
            ..:.|..|:.   ||..::.|..:.:..|.||.||.......|.||||||.|:.|..:|::.|
Human   499 TGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	128/566 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	94/417 (23%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940