DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	549	Identity:	130/549 - (23%)
Similarity:	232/549 - (42%)	Gaps:	83/549 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILAKCGDFNRYQFMILALFGFINIIVS-----MHYF----------TQTVISFVPDHWCYHD 52
            |..::...|:|..:|:.::.| .||..|:|     .|:|          |..::...|:  ...|
Mouse    51 FASVMDAIGEFGTFQWRLVVL-TFIPSILSTFFIFSHHFLLTAQRPYCNTSWILEVGPN--LTED 112

  Fly    53 KLVNMTYKEIGE-------IYAQFENPSCTRLDDI--NGHNVTVSSKACEKWIYNYDFGY-RSMN 107
            :.:|:|......       :|.    |....||.|  .|.|.|.:.|.  .||  |.|.: ||:.
Mouse   113 EQLNLTLPRAPNGSFLTCLMYI----PVPWDLDSIIHFGLNYTETCKF--GWI--YPFAHTRSLI 169

  Fly   108 TELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVA 172
            .|.:.||.:......|.::|..|.:.|:|.:|.||||:||.|.::||........|.|.|..|..
Mouse   170 NEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLLGFLIFGFGTAFVSSFY 234

  Fly   173 TFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGL---FYCLGLVFTPWLAVLVGHW 234
            .:...||....|:.........:|:|::....|.    .||.|   |..:|::....||..|.||
Mouse   235 QYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRA----QAVILQHSFLTIGVILLTGLAYKVVHW 295

  Fly   235 QIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQ 299
            ::......:|:..::...:|::||.:||:.|..::.|...|...|:.|...:.....:|.:
Mouse   296 RLLCLLGGMPMFPLICNIWVLRESPRWLMVRGKVEEAKKVLCYAAEVNKKTIPLNLLNELQ---- 356

  Fly   300 MTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVE--GMGISPFIMFSL 362
                 :.|....:|::||......:.|  ::|....:..|:.|.:.:.|::  ..|:..:.:..:
Mouse   357 -----ISGKKVAKASILDFCTNQHLFK--VVLAIGCVWFTVSYISFTLNLKMNDFGLDVYFVQMV 414

  Fly   363 SALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFG 427
            .::..:|:.:..::|.:..|||...:.:|.   |.|:.....:...|...:.|:|..:  .|.|.
Mouse   415 RSIVAVPARLCCIILLEYFGRKWALNLTLF---LVTSMCLFLLFLPQEPKSTIILTLM--LAEFS 474

  Fly   428 VAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGS 492
            :|.:......|..||:||.:|..|:..|.:|..|.:..:..|      ||...:.:  .:||.
Mouse   475 MAGTLSIFFIYTAELLPTVLRSTGLGMVSLAWVAGAISSVAI------FKQTKTQL--PIFFC-- 529

  Fly   493 FVCL----------LLPETLNRSLPTTIE 511
              ||          |:|||.::||..:||
Mouse   530 --CLCCVLALCFSSLVPETGSQSLRDSIE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	127/537 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	88/388 (23%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	127/536 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030