DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	147/584 - (25%)
Similarity:	251/584 - (42%)	Gaps:	102/584 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFM-ILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYK---- 60
            |.|.::|.:.|...|:|.: .:||...| :.|:.....:...:.||.|.|:...|.|.|.:
  Rat     1 MAFPELLDRVGGRGRFQLLQAVALVTPI-LWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIP 64

  Fly    61 -EIGE--IYA---------------QFENPSCTRLDDINGHNVTVS------SKACEK-WIYNYD 100
             :.|.  :.|               :|..|....::.    |.|.:      ::.||. |:|::.
  Rat    65 GDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIES----NTTATNWSDADTEPCEDGWVYDHS 125

  Fly   101 FGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSN-FCGFAGDFS 164
            ....::.|..:.||||.....:.||:|..|.:||....|..||:.||...|..|. ....:|..:
  Rat   126 TFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIA 190

  Fly   165 TIFTKSVATFTL-CRF-------ISGLAADTNFYLMYIIVL---EYIRPSMRTLGLNMAV----- 213
            .:    :.||.| |.|       ::|:..:|....|:.:||   .|::....|..|.:||
  Rat   191 AL----MPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSLLLAVMEWTS 251

  Fly   214 -----------GLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRND 267
                       .|.:..|.|.|..:|..|..|::.....|.|..|..:|.:.:.|||:||:|...
  Rat   252 AQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGR 316

  Fly   268 IDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDDKKQ-------ATLLDMFRTPRMR 325
            :|.::..|:|||..|. |.::||        .:|.|:|....:::       |.|..:..||.:|
  Rat   317 LDQSLRELQRVAAVNR-RKAEAD--------TLTVEVLRSAMQEEPNGNQAGARLGTLLHTPGLR 372

  Fly   326 KNTLILFFKSMVITLCYDA-------VSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGR 383
            ..|.|    ||   ||:.|       ::.:::.:|.:.|::.:|..:..||..:..:||..|:||
  Rat   373 LRTFI----SM---LCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGR 430

  Fly   384 KGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTCVR 448
            :...:.||::.|| ...|.|.:..:.    .||.:.|.:.....:..::...:.:::||.||.:|
  Rat   431 RLCQASSLVLPGL-CILANILVPREM----GILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIR 490

  Fly   449 GQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEE 512
            ...|....||....:.|.|.:..||.:....|.::.||:........||||||.|..||.||::
  Rat   491 MTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	142/569 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	105/415 (25%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	115/456 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346838
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950