DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a30

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_795976.1	Gene:	Slc22a30 / 319800	MGIID:	2442750	Length:	552	Species:	Mus musculus

Alignment Length:	589	Identity:	144/589 - (24%)
Similarity:	249/589 - (42%)	Gaps:	80/589 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFM----ILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKE 61
            |.|.::|.:.|...|:|.:    :|.|.|.:...::|..||    :.:|:|.|:...|.|.|..:
Mouse     1 MAFQELLNQVGSLGRFQILQISFVLFLVGLVVPHITMENFT----AAIPNHRCWAPILDNDTASD 61

  Fly    62 IGE--------------IYAQFENPSCTRLDDINGH----NVTVSSKA------C-EKWIYNYDF 101
            .|.              :.:......|.|......|    |.|.|::.      | :.|:|:...
Mouse    62 NGSRILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNETEPDTEPCVDGWVYDRSN 126

  Fly   102 GYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCG---FA-GD 162
            ...::.||.:.||:|.....:.:..|.||..:|.:..|.|||:.||  ..||:  |.   || .:
Mouse   127 FLSTIVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGR--KFILT--CALLQFAITE 187

  Fly   163 FSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYC---LGLVFT 224
            ....|..|...:.|.||::|::.:......::::||:..|..    |.|...|..|   :|.:..
Mouse   188 TCVAFAPSFFIYCLLRFLAGMSVEPISVNSHLLMLEWTSPKF----LGMVAVLTSCAASIGYMIL 248

  Fly   225 PWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQA 289
            ..||.|...|:......|:||...::....:.|||:||:..|.....:..|::||..||.:.|..
Mouse   249 AGLAFLFRIWRHLQLAMSVPIFFFLILTRWMSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGN 313

  Fly   290 DFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGI 354
            ..........|.:|:...  |::::..|:|.||.:||...:|.|...:.|:....:|.:::.:..
Mouse   314 TLTMEVVEASMKNELEAA--KRKSSPRDLFHTPILRKRICVLSFMRYLFTISIFGLSLHLQHLST 376

  Fly   355 SPFIM-FSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLA 418
            :..:: |..|||.:| .||:...:.:.:||:......:.:.|:|...|  ....|:.....|::|
Mouse   377 NIILLQFLSSALGIL-ISVIGHFVLNHMGRRITQLVLMSLRGIFMLTA--VFVPQEMQTLRIIMA 438

  Fly   419 CLTIA-ARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSI 482
            .|..| :...:.:|    :.:..||:||.:|..|:..:.:.|.:..||||..:.|.|:....|.|
Mouse   439 TLAAALSSLCMCVS----NLHINELLPTTLRATGMGVIAMFGNSGLFLAPLFMLLATYSANLPWI 499

  Fly   483 ILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESELEKYKRK 547
            ..|.......|...|||||.|:.||.:|                     ||......|..:.|.:
Mouse   500 FYGGFSILYGFSVFLLPETKNQPLPDSI---------------------HDVGNDWKESRQAKEE 543

  Fly   548 HSLI 551
            .|:|
Mouse   544 DSII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	134/535 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	97/382 (25%)
Slc22a30	NP_795976.1	2A0119	11..525	CDD:273328	133/534 (25%)
Slc22a30	NP_795976.1	MFS	151..516	CDD:119392	97/381 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940