DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	133/546 - (24%)
Similarity:	237/546 - (43%)	Gaps:	60/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEIY 66
            |:|::.|..|::..:|.:|..|.....|....:..:...::..|:|.|.....||::
  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLS-------- 59

  Fly    67 AQFENPSCTRLDDINGHNVTVSSK------------------------------ACEKWIYNYDF 101
            :.:.|.|.. |:..:|..|..|.:                              ..:.|.||.|.
  Rat    60 SAWRNHSIP-LETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDV 123

  Fly   102 GYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTI 166
            ...::.||.:.||...:||.:..||||:|.::|:...|.|||:.||...|.|:........|..:
  Rat   124 FLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQL 188

  Fly   167 FTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLV 231
            |:.:...||:...:.|:...:|:...:::..|.:..|:|.:...:.|.:||..|.:..|..|..:
  Rat   189 FSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFI 253

  Fly   232 GHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRR 296
            ..|::.|...::|.:|....::.:.||.:||:::..:..|.|.:::.|||||.......||
  Rat   254 RDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFD---- 314

  Fly   297 HCQMTHEMLGGDDKKQAT--LLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIM 359
                ..|:...:.||..:  :.|:.||..:|..|::.....:.|::.|..:|.:...:....::.
  Rat   315 ----PSELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVN 375

  Fly   360 FSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGG---LFTAAAGIAIAYQQHNHNAILLACLT 421
            ..|.|...:|:.||..||...:.|:...|.:|.:||   ||.......:.|        |...|.
  Rat   376 CFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFY--------LSTALV 432

  Fly   422 IAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGV 486
            :..:||:..:|.....|..||.||.||..||.....|....|.|:||.::||.:.:..|.|::|.
  Rat   433 MVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGS 497

  Fly   487 LFFAGSFVCLLLPETLNRSLPTTIEE 512
            |....:.:.|..||:....||.||::
  Rat   498 LTILTAILTLFFPESFGAPLPDTIDQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	128/532 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	98/378 (26%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	128/532 (24%)
		MFS	123..510	CDD:119392	104/402 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950