DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	129/562 - (22%)
Similarity:	243/562 - (43%)	Gaps:	50/562 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIG-- 63
            |.|:.:|.:.|...|:|.:.:.:.....::::.|...|...:.:|.|.|......|:: |:.|
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLS-KDGGLE 64

  Fly    64 ---EIYAQFENPSCTRL------------DDINGHNVTVSSKAC-EKWIYNYDFGYRSMNTELNW 112
               .:..|.:..||.|.            .:.||..||   :.| :.|:|:......::.||.|.
  Rat    65 AWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVT---EPCIDGWVYDNSTFPSTIVTEWNL 126

  Fly   113 VCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLC 177
            ||......::.|||:.:|.::|.:.:|.|:|::||...|||:............:..:...:.:.
  Rat   127 VCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVF 191

  Fly   178 RFISGLAADTNFYLMYIIVLEYI----RPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYL 238
            |.:||::..:.......:.:|::    |..:.||     :|..|.||......:|..|.||:...
  Rat   192 RLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTL-----IGYVYSLGQFLLAGIAYAVPHWRHLQ 251

  Fly   239 ACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQA--DFDEFRRHCQMT 301
            ...|:|..:..:|.:...|||:|..:...:|..:..|:|||:.||.:...|  ..:..|...|..
  Rat   252 LVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKE 316

  Fly   302 HEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALA 366
            ..:    .|.||:.:::.|.|.:|...|.|.......:..|..:..:::|.|:|.:::..:....
  Rat   317 LTL----SKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAV 377

  Fly   367 VLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAIS 431
            .||:..:..|:.:.:||:.....|||:.|:.....||.     ...:.|:...|.:..:..:|.|
  Rat   378 DLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGII-----PKSHTIIRTSLAVLGKGCLASS 437

  Fly   432 YESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCL 496
            :.....|..||.||.:|..|:..........|.::|.:.....|:.:.|..|.|.:....|.|..
  Rat   438 FNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTA 502

  Fly   497 LLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESE 538
            ||||||.:.||.|:::.:...:|::        |:...|:.:
  Rat   503 LLPETLGQPLPDTVQDLKSRSRGKQ--------NQQQQEQQK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	122/521 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	87/379 (23%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	122/521 (23%)
		MFS	135..505	CDD:119392	88/383 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		4/31 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950