DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	598	Identity:	146/598 - (24%)
Similarity:	251/598 - (41%)	Gaps:	89/598 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIG-E 64
            |.|.::|.:.|...|:|.:.:.....:|.||..|...:...:.:|:|.|:...|.|.|..:.| .
Mouse     1 MSFQELLNQVGSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRCWVPILDNDTASDNGSR 65

  Fly    65 IYAQ-------FENPSCTRLD-------------DINGHNVTVS---SKAC-EKWIYNYDFGYRS 105
            |.:|       ....|..|||             .:||....||   ::.| :.|:|:......:
Mouse    66 ILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLST 130

  Fly   106 MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGR----VPALI---LSNFC-GFAGD 162
            :.||.:.||:|.....:.:..|.||..:|.:..|.|||:.||    ..||:   ::..| .||..
Mouse   131 IVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPS 195

  Fly   163 FSTIFTKSVATFTLC--RFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYC---LGLV 222
            |          |..|  ||::|::.:......::::||:..|....:   ||| |..|   :|.:
Mouse   196 F----------FIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAM---MAV-LSSCAPNIGFM 246

  Fly   223 FTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVS 287
            ....||.|...|.......|.||...::....:.|||:||:..|.....:..|::||..||.: :
Mouse   247 ILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMK-N 310

  Fly   288 QADFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGM 352
            ..|.........|..|:...  |.:.:|.|:|.|..:||...:|.|..:..|:....::.:::.:
Mouse   311 SGDLTMEIVRTSMKAELEAA--KTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQHL 373

  Fly   353 GISPFIM-FSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAIL 416
            ..:..:: |.:||||:| .||:...:.:.|||:......:.:.|:|...|  ....|:.....|:
Mouse   374 SSNIILLQFLISALAIL-VSVIGPFVLNHIGRRITYLVLMSLRGIFIMIA--VFVPQEMQTLRII 435

  Fly   417 LACLTIAARFG---VAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKA 478
            :|  |:|....   |.:|:    .:..||:||.:|...:..:...|.:..||:|..:.:.|::..
Mouse   436 MA--TLAGGISSLCVGVSH----LHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYAN 494

  Fly   479 APSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESELEK 543
            .|.|..|......:|...|||||.|:.||                     .:.||......|..|
Mouse   495 LPWIFYGGFSIFNAFTVFLLPETKNQPLP---------------------DSTHDVGNDWKESRK 538

  Fly   544 YKRKHSLIDAKQM 556
            .||:..:|...::
Mouse   539 GKREDPIIKVTRL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	136/539 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	97/390 (25%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	106/431 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940