DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	561	Identity:	135/561 - (24%)
Similarity:	242/561 - (43%)	Gaps:	76/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCY--------------- 50
            |.|..:|...|...|:|.:.:|.....|:|...|...:...:....|.|:
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSG 65

  Fly    51 ---HDKLVNMTYKEIGEIYAQFENPSCTR-------LDDING--HNVT-VSSKAC-EKWIYNYDF 101
               .|.|:.::.    .:.:......|.|       |...||  .|:| ..::.| :.|:|:...
Mouse    66 ILSQDDLLRISI----PLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMDGWVYDQRT 126

  Fly   102 GYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGR-------VPALILSNFCGF 159
            ...:..||.|.||.|.....:.:.:|.||.:.|....|.||||.||       :..:.::..|
Mouse   127 FLSTTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAITGTC-- 189

  Fly   160 AGDFSTIFTKSVATFTLCRFISGLA---ADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGL 221
                 |....:...:.|.||::||.   .:||..|   ::||:..|..:.|...:::...:..||
Mouse   190 -----TALAPTFFIYCLLRFLTGLCIIPINTNSVL---LMLEWTSPKTQALVTTLSMSSHHFGGL 246

  Fly   222 VFTPWLAVLVGHWQIYLACTSLPI-LLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCR 285
            :.. .||....:|.......|:|| :|::.....:.|||:||:..|....|:..|::||..||.:
Mouse   247 ILA-GLAFAFQNWHHLQLAISVPIFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASKNGIK 310

  Fly   286 VSQADFDEFRRHCQMTHEM---LGGDD----KKQATLLDMFRTPRMRKNTLILFFKSMVITLCYD 343
            .|:.         .:|.|:   :..|:    :.:.:|.|:|..|.:||...:|.....:......
Mouse   311 NSED---------VLTMEVVRTIMKDEIAIPRTKPSLRDLFHMPNLRKRLCLLCLLRFLQISPTV 366

  Fly   344 AVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQ 408
            .::.|::.:..:.|:..||::...:|::.|...|.:.|||:.......|:.|:|.    ::|...
Mouse   367 GINMNLQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFL----LSIVSV 427

  Fly   409 QHNHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLG 473
            ......:|:..:|:|.. ..|:.|.|...|::||:||.:|...:..:.:.|...:.|:|.|:.|.
Mouse   428 PQEMQTLLVVLITLAGG-SSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILT 491

  Fly   474 TFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGE 514
            .:..:.|.||.|||...|..:.|:||||.|:.||.:|::.|
Mouse   492 LYSASLPWIIYGVLSILGGLLPLILPETKNQPLPDSIQDVE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	130/544 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	96/391 (25%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	103/421 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030