DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_036015188.1	Gene:	Slc22a22 / 210463	MGIID:	2446114	Length:	587	Species:	Mus musculus

Alignment Length:	616	Identity:	140/616 - (22%)
Similarity:	233/616 - (37%)	Gaps:	167/616 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHD---------KLVN 56
            ||||:||...||..|:|..::.|...:::::|.|...:...:.:|.|.|..:         ..:|
Mouse     1 MDFDEILHHVGDSGRFQICMIILLNILSLVLSPHDVLENFTAAIPAHHCSINLDNSRSEVSTDMN 65

  Fly    57 MTYKEIGEIYAQF---ENP-SCTR--------LD-DINGHNVT-VSSKAC-EKWIYNY------- 99
            :|.:::.::....   :.| .|.|        || :|:..|.| :.::.| :.|.|::
Mouse    66 LTTEDLMKVSIPMGPNQKPEQCRRFRYTQWQFLDSNISTFNSTELETEPCLDGWTYDHSVFTSTI 130

  Fly   100 --------------------------DFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFY 138
                                      :.|.:|.....:.|||........|:....|.:|.....
Mouse   131 VTEGLSPPQPWDSDQYYHTKHEISPCEEGLKSSVKVWDLVCDFQSFKYYAQATSLAGHLVSCPLS 195

  Fly   139 GLLSDKIGRVPALI--------LSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYII 195
            |::||:.||.|.|:        :..:|.||.:||        .:.:.||:......|......|:
Mouse   196 GIISDRFGRKPLLMYCSLAYGAVGTYCAFAPNFS--------VYCVLRFLLSAFQSTILINSLIL 252

  Fly   196 VLEYI----RPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQ 256
            |||..    .|::..|.     |||..:|......||.::..|.:.....:||..:..:.:..|.
Mouse   253 VLEEASVQWHPTIIVLS-----GLFNSIGQGVLGGLAYVISDWHLLQLAYALPFFIFFVLFCWVP 312

  Fly   257 ESAQWLVTRNDIDGAIVRLKRVAKFNGCR-VSQADFDEFRRHCQMTHEMLGGDDKKQAT------ 314
            ||.:||:.....|.|...|:|:|..||.: ::|          .:|.|.|....||...
Mouse   313 ESVRWLIITGKTDQAWKELQRIASINGKKGIAQ----------NLTTEDLRSKLKKDVNSTGKLF 367

  Fly   315 -LLDMFRTPRMRKNTLILFFKSMVITLCYDAVS--RNVEGMGISPFI-MFSLSALAVLPSSVLLV 375
             :.|:|..|.:||  ::|...|::....:..|.  .:|:.:|.:.|: ...|.|:.| ||..|..
Mouse   368 RIKDIFINPLIRK--IVLSNSSLLFAELFSFVGLLLDVQLLGKNMFLTQIFLGAIDV-PSKSLTY 429

  Fly   376 LLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYES------ 434
            .....:.|:.:.:..||..|                      :|:||.    :.||.|.
Mouse   430 FTIRNVSRRPLIAFLLLTTG----------------------SCITIT----IFISEEMYVLRTI 468

  Fly   435 ---------------GSQYATELIPTCVR----GQGVAAVHVAGFAASFLAPYILWLGT--FFKA 478
                           .:.|..||.|..:|    |..:|.|.:||..::      |.|.|  :|..
Mouse   469 IFILGKGCFAAFTCISTTYINELSPVELRSTLNGVFLAVVRLAGVLSA------LTLATRKYFVY 527

  Fly   479 APSIILGVLFFAGSFVCLLLPETLNRSLPTT 509
            .|.|:.|||....:...|.||||.|  ||.|
Mouse   528 LPMILYGVLPIVATISILFLPETFN--LPHT 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	133/604 (22%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	97/423 (23%)
Slc22a22	XP_036015188.1	MFS_OAT	108..548	CDD:340932	107/497 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.030