DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	146/552 - (26%)
Similarity:	252/552 - (45%)	Gaps:	45/552 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTY--KEIG 63
            |.|..:|.:.|...|:|.:.:......|||:|.|...:...:.:|:|.|:...|.|.|.  .:.|
  Rat     1 MAFQDLLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNG 65

  Fly    64 EIY------------AQFENPSCTR-------LDDINGHNVTVS---SKAC-EKWIYNYDFGYRS 105
            .:.            :......|.|       |..:||...:|:   ::.| :.|:|:......:
  Rat    66 NLSQDDLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVDGWVYDQSTFLST 130

  Fly   106 MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKS 170
            :.||.:.||:|.....|.:.||..|.:||.:.||.|:|:.||...||.::......:....|..:
  Rat   131 IITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAFAPT 195

  Fly   171 VATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLV---FTPWLAVLVG 232
            ...:...||::|::..|......::::|:.||..:.|    |.||..|.|.:   ....||..|.
  Rat   196 FLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQAL----ATGLLLCAGAIGQTVLAGLAFTVR 256

  Fly   233 HWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRH 297
            :|.......|:||..:::....:.|||:||:..|.:...:..|.:||..||.:.|..........
  Rat   257 NWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIEVVR 321

  Fly   298 CQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSL 362
            ..|..|:.....|  ::|.|:||||.:||...:|.....|:.|....:..|.:.:.|:.|::..|
  Rat   322 TIMKEELEASQTK--SSLWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQHLRINVFLLQCL 384

  Fly   363 SALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFG 427
            ..:..:|::::.:.|.:.:||:   ...|.:..||..:. :||.:.......:.:    :.|.||
  Rat   385 LGIITIPANLVGIFLVNHLGRR---ISQLFIISLFGISI-LAIIFVPQEMQILRM----VLATFG 441

  Fly   428 VAISYESGSQ---YATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFF 489
            ...|:.|.|.   :|.||:||.:|...:..:.:||...:.|:|..:.|.|:..:.|.||.|||.|
  Rat   442 GVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLPWIIYGVLSF 506

  Fly   490 AGSFVCLLLPETLNRSLPTTIEEGEVFGKGER 521
            .|..|.||||||.|:.||.:|::.|..|:..|
  Rat   507 LGGLVVLLLPETKNQPLPDSIQDVENEGRASR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	139/528 (26%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	102/379 (27%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	138/527 (26%)
		Aldolase_II	39..>85	CDD:294146	7/45 (16%)
		MFS	125..506	CDD:119392	103/394 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940