DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6231 and F45E10.2

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001022174.1	Gene:	F45E10.2 / 185801	WormBaseID:	WBGene00009729	Length:	538	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	132/522 - (25%)
Similarity:	238/522 - (45%)	Gaps:	67/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQT-VISFVPDHWCYHDKLVNMTYKEIGEIYA 67
            :.|....|.|.|:|.:...|.......||||..:.| |:|  |..     |:.|.|.:
Worm    69 ESIFEGLGSFGRFQQIQFILICIPIAFVSMHVMSWTFVVS--PAR-----KICNETNE------- 119

  Fly    68 QFENPSCTRLDDINGHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSV 132
                   ||:|            .||:..|:....: .|:.:..|:     :|.: |:::|||.:
Worm   120 -------TRID------------GCEELAYSASDRW-EMDGDNGWI-----RATV-QAVYFIGQM 158

  Fly   133 VGTLFYGLLSDKIGRVP----ALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMY 193
            :|:...|:::|||||..    .|:|...|...    .|...:...:.:.:..:|......:.:..
Worm   159 IGSFTCGVMADKIGRKKVLFWCLVLQVVCALL----LIVAPTWWIYAILKAGTGFTQPGIYGVAV 219

  Fly   194 IIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQES 258
            ::.:|.:....|:. :.:...:|..:|.|....:|..:..:::..|..::|.|:.:.||:::.||
Worm   220 VLGIELVGKKYRSF-IAVIANVFGVIGGVLLAVMAYFIVDYRLLHASIAIPSLIFITYYWMIHES 283

  Fly   259 AQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDDKKQA-TLLDMFRTP 322
            |:|||::...|.|.|.|...|.:|...:.:...::..:...:|     ...||.: .:.|:.|||
Worm   284 ARWLVSQEKYDDANVVLCATANWNKKTIPKNWAEKIEKKMDVT-----ATKKKDSFGVFDLIRTP 343

  Fly   323 RMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMA 387
            :|||.|:..|....|.|:.|..::...:..|.|.|:.|..|.|..||:.:::.||.||:||:.|.
Worm   344 QMRKRTIANFVMWPVTTMMYYGLTMRSDVGGGSLFVTFVTSQLMELPAVIIVALLIDRLGRRIMY 408

  Fly   388 SGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGV 452
            ||::...|:...|:.:........:..|:|    :.|:..|:::|.....|.:||.||.:|...|
Worm   409 SGAIFTAGMLLLASWLTHDLIPSQYAVIML----MVAKGAVSVAYTVMYTYTSELFPTVIRNTAV 469

  Fly   453 AAVH-VAGF---AASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVC-LLLPETLNRSLPTTIEE 512
            .... :|.|   :|||:|.::  :..|.:....|...:|....|.|. .:||||:|:.||.:|.|
Worm   470 GCCSTIARFGAISASFIAFFL--VDRFGRIVMIIPFTILALCASIVSWTMLPETVNQQLPDSISE 532

  Fly   513 GE 514
            .|
Worm   533 VE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	128/508 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	95/383 (25%)
F45E10.2	NP_001022174.1	MFS_SLC22	121..518	CDD:340875	104/431 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010