DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	569	Identity:	134/569 - (23%)
Similarity:	249/569 - (43%)	Gaps:	61/569 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIG-- 63
            |.|:.:|.:.|...|:|.:.:.:.....::::.|...|...:.:|.|.|......|:: |:.|
Mouse     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLS-KDGGLE 64

  Fly    64 ---EIYAQFENPSCTRL------DDINGHNVTVSSKAC-EKWIYNYDFGYRSMNTELNWVCDSAY 118
               .:..|....||.|.      .:.||..||   :.| :.|:|:......::.||.|.||....
Mouse    65 AWLPLDKQGRPESCLRFPFPHNGTEANGTGVT---EPCLDGWVYDNSTFPSTIVTEWNLVCSHRA 126

  Fly   119 KARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGL 183
            ..::.||||.:|.::|.:.:|.|:|::||...|||:............:..:...:.:.|.:||:
Mouse   127 FRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGM 191

  Fly   184 AADTNFYLMYIIVLEYI----RPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLP 244
            :..:.......:.:|::    |..:.||     :|..|.||......:|..|.||:......|:|
Mouse   192 SLASIAINCMTLNMEWMPIHTRAYVGTL-----IGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVP 251

  Fly   245 ILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGD- 308
            ..:..:|.:...|||:|..:...:|..:..|:|||:.||.:...|         :::.|:|...
Mouse   252 FFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGA---------KLSIEVLQTSL 307

  Fly   309 ------DKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAV 367
                  :|.||:.:::.|.|.:|:..|.|.......:..|..:..:::|.|:|.:::..:.....
Mouse   308 QKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVD 372

  Fly   368 LPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISY 432
            ||:..:..|:.:.:||:.....|||:.|:.....||.    ...| .|:...|.:..:..:|.|:
Mouse   373 LPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGII----PRGH-TIIRTSLAVLGKGCLASSF 432

  Fly   433 ESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLL 497
            .....|..||.||.:|..|:..........|.::|.|.....|:.:.|..|.|.:..|.|.|..|
Mouse   433 NCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTAL 497

  Fly   498 LPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESELEKYKR 546
            |||||.:.||.|:::               |.::...::.:.:||:.|:
Mouse   498 LPETLGQPLPDTVQD---------------LKSRSRGKQKQQQLEQQKQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	126/520 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	91/384 (24%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	126/520 (24%)
		MFS	129..499	CDD:119392	92/388 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844046
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950