DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a27

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	591	Identity:	144/591 - (24%)
Similarity:	247/591 - (41%)	Gaps:	85/591 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGE- 64
            |.|.::|.:.|...|:|.:.:.....:|.||..|...:...:.:|:|.|:...|.|.|..:.|.
Mouse    26 MSFQELLNQVGSLGRFQILQIVFLLLLNAIVVPHIAMENFTAAIPNHRCWVPILDNDTASDNGSR 90

  Fly    65 -------------IYAQFENPSCTR-------LDDINGHNVTVS---SKAC-EKWIYNYDFGYRS 105
                         :.:......|.|       |..:||....||   ::.| :.|:|:......:
Mouse    91 ILSQDDLLRISIPLDSNLRPEKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLST 155

  Fly   106 MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGR----VPALI---LSNFC-GFAGD 162
            :.||.:.||:|.....:.:..|.||..:|.:..|.|||::||    ..||:   ::..| .||..
Mouse   156 IVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFILTCALLQFAITETCVAFAPS 220

  Fly   163 FSTIFTKSVATFTLC--RFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYC---LGLV 222
            |          |..|  ||::||:.:......::::||:..|..    |.|...|..|   :|.:
Mouse   221 F----------FIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKF----LTMMAALLSCAPNIGYM 271

  Fly   223 FTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVS 287
            .:..||.|...|.......|:||...::....:.|||:||:..|.....:..|::||..||.: :
Mouse   272 ISAGLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMK-N 335

  Fly   288 QADFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGM 352
            ..|.........|..|:...  |.:.:|.|:|.|..:||...:|.|..:..|:....::.:::.:
Mouse   336 SGDLTMEIVRTSMKAELEAA--KTKPSLRDLFHTSILRKRICVLSFMRLFFTVSIFGLAVHLQHL 398

  Fly   353 GISPFIM-FSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAIL 416
            ..:..:: |.:||||:| .||:...:.:.|||:......:.:.|:|...|  ....|:.....|:
Mouse   399 SSNIILLQFLISALAIL-VSVIGPFVLNHIGRRITYLVLMSLRGIFILIA--VFVPQEMQTLRII 460

  Fly   417 LACLTIA-ARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAP 480
            :|.|... :...|.:|    ..:..||:||.:|...|..:...|.:.|||:|..:.|.|::...|
Mouse   461 MATLAEGISSLCVGVS----RLHTNELLPTTLRATAVGVIGFFGNSGSFLSPLFMLLATYYANMP 521

  Fly   481 SIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESELEKYK 545
            .|..|......:|...|||||.|:.||                     .:.||......|..|.|
Mouse   522 WIFYGGFSIFNAFTVFLLPETKNQPLP---------------------DSTHDVGNDWKESRKGK 565

  Fly   546 RKHSLI 551
            ::..:|
Mouse   566 KEDPII 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	135/537 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	99/388 (26%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	108/429 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843930
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940