Protein Alignment CG6231 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_001262734.1
• Gene: CG6231 / 42339
• FlyBaseID: FBgn0038720
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 144/586 - (24%)
• Similarity: 240/586 - (40%)
• Gaps: 106/586 - (18%)

  Fly     1 MDFDQILAKCGDFNRYQFM-ILALFGFINIIVSMHYFTQTVI----SFVPDHWCYHDKLVNMTYK 60
            |.|.::|...|...|:|.: .:||     ::..|...||:::    :.||.|.|:...|.|.|.:
Human     1 MAFSELLDLVGGLGRFQVLQTMAL-----MVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

  Fly    61 E--IGEIYAQ--------------------FENPSCTRLDDINGHNVTVSS------KAC-EKWI 96
            .  :|.:..:                    |..|....||.    |.|.:|      :.| :.|:
Human    61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDP----NATATSWSEADTEPCVDGWV 121

  Fly    97 YNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNF----C 157
            |:......::..:.|.||||.....:.||::..|.:||....|..||:.||...|..|..    .
Human   122 YDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVM 186

  Fly   158 GFAGDFSTIFTKSVATFTLCRF-----ISGLAADTNFY--------------------LMYIIVL 197
            |.|..|:..|    ..:.|.||     ::|:..:|...                    |..:.|:
Human   187 GTAAAFAPAF----PVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVM 247

  Fly   198 EY----IRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQES 258
            |:    .||.:.||.   ::|..:..||  |..:|..|..|.:.....|:|..|..||.:.:.||
Human   248 EWTAARARPLVMTLN---SLGFSFGHGL--TAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 307

  Fly   259 AQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPR 323
            |:||:|...:|..:..|.|||..||....|...........|..|:..|  :..|:|..:.|.|.
Human   308 ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMG--QPPASLGTLLRMPG 370

  Fly   324 MRKNTLILFFKSMVITLCYDA-------VSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRI 381
            :|       |::.:.|||:.|       ::.:::.:|.:.|::.....:..:|:.:..:||...:
Human   371 LR-------FRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHL 428

  Fly   382 GRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTC 446
            ||:...:.|||:.||...|..:.    .|...| |.:.|.:....||..::...:.|::||.||.
Human   429 GRRPTLAASLLLAGLCILANTLV----PHEMGA-LRSALAVLGLGGVGAAFTCITIYSSELFPTV 488

  Fly   447 VRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIE 511
            :|...|....:|....:.|.|.:..||......|.::.|.:........||||||.:..||.||:
Human   489 LRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQ 553

  Fly   512 E 512
            :
Human   554 D 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	139/571 (24%)
		MFS	125..499	CDD:119392	101/413 (24%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	139/571 (24%)
		MFS	122..541	CDD:119392	108/441 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950