DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and SLC22A9

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_543142.2	Gene:	SLC22A9 / 114571	HGNCID:	16261	Length:	553	Species:	Homo sapiens

Alignment Length:	566	Identity:	131/566 - (23%)
Similarity:	228/566 - (40%)	Gaps:	76/566 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIG-- 63
            |.|..:|...||..|:|.:.........:...:|:..:...:|:|.|.|:...|.|.|..:..
Human     1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTG 65

  Fly    64 --------------------EIYAQFENPSCTRLDDINGHNVTVSSKACEK----WIYNYDFGYR 104
                                |...:|.:|. .:|..:||.....|....|.    |:|:......
Human    66 ALSQDALLRISIPLDSNMRPEKCRRFVHPQ-WQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSS 129

  Fly   105 SMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGR--------VPALILSNFCGFAG 161
            ::.||.:.||||.....:.:.:|..|.:||.:..|.|||:.||        :...|:......|.
Human   130 TIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP 194

  Fly   162 DFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYC-LGLVF-- 223
            .|        ..:...||:||:||.:......:::.|:.....:.:|:.:.:    | .|:.|
Human   195 TF--------LIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGM----CPSGIAFMT 247

  Fly   224 TPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQ 288
            ...||..:..|.|.....|:|..::.|....:.|||:||:..|..:..:..|::.|..:|.:.::
Human   248 LAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNAR 312

  Fly   289 ADFDEFRRHCQMTHEMLGGD--------DKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAV 345
            .         .:|.|:|...        .||:.:|.:|...|.:.|...:|.|......:.|..:
Human   313 D---------TLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGL 368

  Fly   346 SRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQH 410
            :.:|:.:|.:.|::.:|....:|.::.:.......:.|:  ||..||:..|......|....|:.
Human   369 NLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRR--ASQMLLMFLLAICLLAIIFVPQEM 431

  Fly   411 NHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTF 475
            .....:||.|.:.|.   |::......:..|:|||.:|.:.:.........|..|||.::.|..:
Human   432 QTLREVLATLGLGAS---ALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVY 493

  Fly   476 FKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGER 521
            ....|.||.||..|...|..||||||.|:.|..||::    .|.||
Human   494 SPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQD----EKNER 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	123/542 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	89/392 (23%)
SLC22A9	NP_543142.2	Sugar_tr	11..527	CDD:331684	123/542 (23%)
SLC22A9	NP_543142.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..553		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940