DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	545	Identity:	130/545 - (23%)
Similarity:	239/545 - (43%)	Gaps:	42/545 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWC-YHDKLVNMTYKEI-- 62
            |.|:::|.|.|.|..:|...|.|......::.||:.....::.||.|.| ..|...|::::::
Mouse     1 MGFEELLHKVGGFGPFQLRNLVLLALPRFLLPMHFLLPIFMAAVPAHHCALPDAPANLSHQDLWL 65

  Fly    63 -----GEIYAQFENPSCTRL------------------DDINGHNVTVSSKACEK-WIYNYDFGY 103
                 .|....|.  ||.|.                  .:..|..:||   .|.: |.|:.....
Mouse    66 KTHLPRETDGSFS--SCLRFAYPQALPNVTLGTEVYNSGEPEGEPLTV---PCSQGWEYDRSEFS 125

  Fly   104 RSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFT 168
            .::.||.:.||......::..:.||||.::|.:.||.|||:.||...|:::.....|....:..:
Mouse   126 STIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVSTLALGLMSAAS 190

  Fly   169 KSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGH 233
            .:...|...|.::|.|......::..:.||::....||:. .:....|:..|::....:..|:..
Mouse   191 VNYIMFVTTRMLTGSALAGFTIIVLPLELEWLDVEHRTVA-GVISTTFWTGGVLLLTLVGYLIRS 254

  Fly   234 WQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHC 298
            |:..|...:||.:..::..:.|.|||:||:|:..::.|...|...||.||..:|:....:...:.
Mouse   255 WRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISEDSLSQEALNK 319

  Fly   299 QMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLS 363
            .:|.|.:    .::.:.||:|||.::|..:|........:...|..::.:..|:|::.:....|.
Mouse   320 VITMERV----SQRPSYLDLFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGLTVYQTQLLF 380

  Fly   364 ALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGV 428
            ....:||.:.:..|...:||:...:|.||...|   ..||::.......:.| .|.:.|...|..
Mouse   381 GAVEVPSKITVFFLVRLVGRRLTEAGMLLATAL---TFGISLLVSSDTKSWI-TALVVIGKAFSE 441

  Fly   429 AISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSF 493
            | ::.:...:.:||.||.:|..|:....:.|...:.|||.::.|...:...|.:..|.:.|..:.
Mouse   442 A-AFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKLAYGGISFLAAC 505

  Fly   494 VCLLLPETLNRSLPTTIEEGEVFGK 518
            ..||||||....||.||::.|..|:
Mouse   506 TVLLLPETKKAQLPETIQDVERKGR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	122/524 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	88/373 (24%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	122/524 (23%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	88/374 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950