DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_598741.2	Gene:	Slc22a13 / 102570	MGIID:	2143107	Length:	551	Species:	Mus musculus

Alignment Length:	540	Identity:	135/540 - (25%)
Similarity:	240/540 - (44%)	Gaps:	56/540 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTY--KEIGEI 65
            |.|::|:.|||.|:|..:..|.|..|.:.:...|.|..:.....|.|....:.|.|:  ....::
Mouse     4 FAQVMAEVGDFGRFQVRLTILMGIPNFLAAFFIFGQVFMVLDEAHHCSVSWVKNHTFNLSAAEQL 68

  Fly    66 YAQFEN---------------PSCTRLDDINGHNVTVSSKACEK-WIYNYDFGYRSMNTELNWVC 114
            .....|               |....|:||..|... .::||:. |.|. :...:|:..|.:.||
Mouse    69 AISIPNDTAGRPESCLMFRPPPDSASLEDILSHRFN-ETQACDSGWDYP-ENRPQSLKKEFDLVC 131

  Fly   115 DSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRF 179
            |.....:..||:|..|.:||.|.:|.:.|.|||.|:|::..........:|.|..|...:...||
Mouse   132 DRKNLKKTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQVLLSGITSMATAFVSSFELYLALRF 196

  Fly   180 I-----SGLAADTNFYLMYIIVLEYIRPSMRTLGL-----NMAVGLFYCLGLVFTPWLAVLVGHW 234
            :     :|....||     :::.|::.||.||..:     |:|:|.....||.:.      |.:|
Mouse   197 VLATANAGFLLSTN-----VLISEWVGPSWRTQAVVLAQSNVALGQMVLAGLAYG------VRNW 250

  Fly   235 QIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQ 299
            ::.....:.|:||:..|::|:.||.:||:::...:.|...:::.|..||..:|.          :
Mouse   251 RLLQITGTAPVLLLFFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLSP----------E 305

  Fly   300 MTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSA 364
            :.::::..........||:||.|.:||.||||.....|.:|.|.::|..|...|:..::...:..
Mouse   306 LLNQLVPEKTGPSGNALDLFRHPHLRKVTLILIAVWFVDSLVYYSLSFQVGDFGLDIYVTQLIFG 370

  Fly   365 LAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVA 429
            ...:|...|.||:.:::|||.....:|.:.|:..    |.|.:...:...: :..|.:..:|..|
Mouse   371 AVEMPGRFLSVLMMEKLGRKWSQLCTLTLAGIMY----IIIIFIPGDLPTV-VTVLAVVGKFASA 430

  Fly   430 ISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFV 494
            .::.....|..||.||.:|..|:..|.:.......:.|.::.|..:.:|.|.:|.|.|......:
Mouse   431 AAFTISYVYTAELFPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHQAIPMVIFGSLPIGAGLL 495

  Fly   495 CLLLPETLNRSLPTTIEEGE 514
            |.|||||..::|..|:::.|
Mouse   496 CALLPETRGQTLKDTLQDLE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	130/525 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	95/383 (25%)
Slc22a13	NP_598741.2	2A0119	12..510	CDD:273328	130/525 (25%)
Slc22a13	NP_598741.2	MFS	139..500	CDD:119392	96/386 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950