DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and slc22a6

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	593	Identity:	139/593 - (23%)
Similarity:	246/593 - (41%)	Gaps:	92/593 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65
            |.|.:||...|...|||.:.:.|......:::.|...|...:.:|.|.|.    :|.:::|
Frog     1 MAFQEILESIGGMGRYQVIHVVLLSLPVFMLASHNLMQNFTAAIPRHRCQ----INGSFEE---- 57

  Fly    66 YAQFENP---------------SCTR---------LDDINGHNVTVSSKAC-EKWIYNYDFGYRS 105
             ..|..|               .|.|         :|:...:...:.::.| :.|:|::.....:
Frog    58 -TNFTGPWLRALVPMKPTGEFSKCLRYTTPQYHLLMDNFTQNVDELETETCVDGWVYDHSEFAST 121

  Fly   106 MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKS 170
            :.|:.:.||:.....::.||::..|.:||::.:|.||||.||.|..|.||...........|:.:
Frog   122 IITQWDLVCNHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQMSVTGICAAFSPN 186

  Fly   171 VATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQ 235
            ...:.:.||::|.|........|.:::|:| |:......:.|.|..|.:|.:....||.::..|.
Frog   187 YIWYCIFRFLTGTALSGIVLNSYSLIVEWI-PTGNRAFTSTATGYCYTMGQLVLVGLAFMIRDWH 250

  Fly   236 IYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQM 300
            ......|||.....||.:.:.||.:|||.....:.|...||:|||.||.:.:..         ::
Frog   251 WLQLAASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGE---------KL 306

  Fly   301 THEMLGGDDKKQA--------TLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPF 357
            |.|:|....:::.        ::||:.|||.:|:.:..:.......:..|..::.:::..|:|.:
Frog   307 TVEVLKSSMQREISASKHSTYSVLDLVRTPVVRRISFCISCTWFSTSFAYYGLALDLQSFGVSIY 371

  Fly   358 IMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACL-- 420
            |:..:.....:|:......:...|||:.:.:.:|::       |||||         ::..|:
Frog   372 IIQIIFGTVDIPAKFFSYFVMTYIGRRVLQALTLIL-------AGIAI---------LVNICVPQ 420

  Fly   421 ------TIAARFG---VAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFF 476
                  |..|.||   :|.|:.....|..||.||.:|..|:....:.......:||.....|..:
Frog   421 DYQTVRTSMAVFGKGCLAASFNCLFLYTGELYPTVIRQSGMGLGTMMARLGGIIAPLAQMTGDIY 485

  Fly   477 KAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFD----FPCLHNKHDDEES 537
            .:.|.||.|.|..........|||||...||.|||:.|...|.::..:    .|.         .
Frog   486 HSLPLIIFGCLPILSGIAGCFLPETLGVPLPETIEDVESSDKKQKNVELSAKMPL---------K 541

  Fly   538 ESELEKYK 545
            |:||..:|
Frog   542 ETELANWK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	125/541 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	94/392 (24%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	101/431 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100