DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6231 and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	586	Identity:	142/586 - (24%)
Similarity:	258/586 - (44%)	Gaps:	69/586 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKL------VNMTY 59
            |.|:.:|::...|.|:|.|:|.:.......:..|:.....|:.:|.|.|....|      .|::.
Zfish     1 MRFEDLLSELNGFGRFQKMVLCINFLGRFSLGCHFLLGNFIAAIPSHHCNISSLDVDGVFENLSQ 65

  Fly    60 KE---IGEIYAQ----------FENPSCTRLDDINGHNVTVSSKA------CEK-WIYNYDFGYR 104
            :|   :| :.||          |.:|....|       :..||.:      |:. |.::......
Zfish    66 EERLTVG-VPAQEDGTPASCHMFSHPQFQLL-------INSSSSSDLPVVECQNGWHFDNSTFIS 122

  Fly   105 SMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTK 169
            ::.|:.:.|||.....::..::||:|.:.|...:|.||...||.|.|::|...|......::.:.
Zfish   123 TLATQWDLVCDKRALGKLTTTIFFLGVMFGAAAFGSLSAMFGRKPMLLVSYILGMGFGLCSVLSS 187

  Fly   170 SVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHW 234
            |:..|.:.||.||.....:..:..::.:|::....|.| :.:...|.:..|.:..|.:|..:..|
Zfish   188 SLVMFAVLRFFSGFTITGSVIISTVLNVEWVSIEHRKL-VGVIDSLAWTFGFMGFPVIAYFIRDW 251

  Fly   235 QIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFN-----GCRVSQADFDEF 294
            :......|||.::.::.::.|.|||:||:.....|.|...||:.|..|     ..|:...|..:.
Zfish   252 RWLTVAISLPNVISIITWWWVPESARWLIVNGKADKAHYYLKKCAAMNHKKEVTARIKPEDLSKI 316

  Fly   295 RRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTL---ILFFKSMVITLCYDAVSRNVEGMGISP 356
                     ::.....::.:.||:.|||:||:.:|   |.:|.  |.|:.| .:|.|:.|.|::.
Zfish   317 ---------IVTDRGSRKYSYLDLVRTPKMRRLSLLTGITWFS--VATVAY-GISFNITGFGLNM 369

  Fly   357 FIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLT 421
            ::...:.....:|:...:..|.|:.||....:||||..|: :....|.|..::    .::...:.
Zfish   370 YLTQFVYGAIEIPAKFCIYYLLDKFGRHVTQAGSLLFVGI-SFIINIFIPKEK----TVIRTVIA 429

  Fly   422 IAARFGVAISYESGSQYATELIPTCVRGQGVA-AVHVAGFAASFLAPYILWLGTFFKAAPSIILG 485
            :..:...|.|:.:...|.:||.||.||..|:. ...:|.|..| :||.||.....:.....:||.
Zfish   430 VLGKGCSATSFGTVILYTSELYPTVVRQNGMGYTSFIARFGVS-VAPLILLSNDVWSYFSQVILC 493

  Fly   486 VLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCLHNKHDDEESESELEKYKRKHSL 550
            .|..:.:||...||||..:.||.||::.|...|.:...   .|.::..:|:...|    |.|.:|
Zfish   494 FLALSAAFVAYQLPETSGKCLPETIDDIEGIRKDKNGL---LLQDRKMEEKDNME----KLKDNL 551

  Fly   551 I 551
            |
Zfish   552 I 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	128/532 (24%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	95/382 (25%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	128/531 (24%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	95/382 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950