Protein Alignment CG17752 and SLC22A2

DIOPT Version :10

• Sequence 1: NP_650817.1
• Gene: CG17752 / 42337
• FlyBaseID: FBgn0038718
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 153/548 - (27%)
• Similarity: 251/548 - (45%)
• Gaps: 61/548 - (11%)

  Fly     6 VLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLISFTPSHRCSAP-VEEFS----------QN 59
            |||..|.|..:|..:..|....:...:..|.....:.|||.|||.:| |.|.|          .|
Human     8 VLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELN 72

  Fly    60 FT--------ELLSCSVIQYDVD-----------MTSFRDNK-------C-SSWDFDKESNYESI 97
            :|        |.......:|:||           :.|...|:       | ..|.:  |:...||
Human    73 YTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVY--ETPGSSI 135

  Fly    98 TTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLST-LTGASGDFFTSFVGS 161
            .||...||.:::.|.:.||...:|..:||:..||:|||.|| ..|:|:| |..|:.....:...:
Human   136 VTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGR-KLCLLTTVLINAAAGVLMAISPT 199

  Fly   162 LPMFSFTRFISGLSMDTQYVLMYILVFEYLSPQH-RTFGLNIILGVFYSIGLMISPWIAIWLGNW 225
            .......|.|.||.....:::.|||:.|::..:: ||.|  |...|.|::||::...:|..|.:|
Human   200 YTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVG--IFYQVAYTVGLLVLAGVAYALPHW 262

  Fly   226 RSYLWAASLPALGMLIFPLFLHESVEWLLTKGKFDKAVNNLKSVAKFNGRQVEDSVFDEFIKHYR 290
            |...:..|||....|::...:.||..||:::.|..:|:..:|.:||.||:.:..|:       .|
Human   263 RWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASL-------QR 320

  Fly   291 EKL-NSAQKKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGF 354
            .:| ....||.:.:|:.::|||::||.|:||:......::.:..|..::...|.:.:..|.||..
Human   321 LRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSAL 385

  Fly   355 VVLPGGLSIILFQNKIGRK-GMACASLLVGAFITATTGYLVGTLDPANYSVLLGFMVCLARFGAV 418
            |..|....|||..::|||: ..|.::::.||      ..|.....|.:...|...:.||.|.|..
Human   386 VEFPAAFMIILTIDRIGRRYPWAASNMVAGA------ACLASVFIPGDLQWLKIIISCLGRMGIT 444

  Fly   419 VAYDAEAQYAAEIIPTSVRGRGVANIHVVGNAFAFFSSYIIY-LGTFYKPLPSLLISFLLIIGAC 482
            :||:......||:.||.:|..||.....:.:.....:.:::| |...:..||.::...|.::...
Human   445 MAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGG 509

  Fly   483 LCLTLPETLHKQLPQTLEEGEIFAKGEK 510
            |.|.||||..|.||:|:||.|...:..|
Human   510 LVLLLPETKGKALPETIEEAENMQRPRK 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	145/529 (27%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	145/529 (27%)
		Proline-rich sequence. /evidence=ECO:0000269|PubMed:26979622	284..288		2/3 (67%)