Protein Alignment CG17752 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_650817.1
• Gene: CG17752 / 42337
• FlyBaseID: FBgn0038718
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 145/550 - (26%)
• Similarity: 258/550 - (46%)
• Gaps: 77/550 - (14%)

  Fly     7 LEKCGNFGPYQ---ILLLGLYGYT------NIV----SSLHYFSQTLISFTPSHRCS-APVEEF- 56
            |::.|.||.:|   .|||.|.|.|      .:|    ...||:.:...:...:.||. :|.||:
Human     8 LQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWN 72

  Fly    57 ----------------------------SQNFTELLSCSVIQYDVDMTSFRDNKCS-------SW 86
                                        |.:.|..|||:      |..:...|:.:       .|
Human    73 RTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCA------DPLAAFPNRSAPLVPCRGGW 131

  Fly    87 DFDKESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTL-TGA 150
            .:.:.  :.:|.:|.:.||.:|:.|.:.|:...:|...|:...||.|||.||:...:||.| .|.
Human   132 RYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGV 194

  Fly   151 SGDFFTSFVGSLPMFSFTRFISGLSMDTQYVLMYILVFEYL-SPQHRTFGLNIILGVFYSIGLMI 214
            :| ...:|..:.|:|...||:.|:.....::..|::|.|.: |.|.|..|  |::.:|:::|::|
Human   195 TG-VVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVG--IVIQMFFTLGIII 256

  Fly   215 SPWIAIWLGNWRSYLWAASLPALGMLIFPLFLHESVEWLLTKGKFDKAVNNLKSVAKFNGRQVED 279
            .|.||.::.||:....|.:||:...|::...:.||..||:|:.|.|||:..|:.:||.||:.:.
Human   257 LPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLS- 320

  Fly   280 SVFDEFIKHYREKLNSAQKKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGIS 344
                   .:|.|...:.::.|:.:|:.::|||::||.|:||:.......:.:..|...:..:|.:
Human   321 -------SNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGN 378

  Fly   345 PFKLFSYSGFVVLPGGLSIILFQNKIGRKGMACASLLVGAFITATTGYLVGTLDPANYSVLLGFM 409
            .:..|..||.|.|||.|.|:|...::||:....||.:|.......|.:|     |...:.|...:
Human   379 LYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFL-----PEGIAWLRTTV 438

  Fly   410 VCLARFGAVVAYDAEAQYAAEIIPTSVRGRGVANIHVVGNAFAFFSSYIIY-LGTFYKPLPSLLI 473
            ..|.|.|..:|::......:|:.||::|..||:....:.:.....:.:::: |...:..||.::.
Human   439 ATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIF 503

  Fly   474 SFLLIIGACLCLTLPETLHKQLPQTLEEGE 503
            ..|..|...|.:.||||....||:|:::.|
Human   504 GILASICGGLVMLLPETKGIALPETVDDVE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	142/539 (26%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	142/539 (26%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		2/3 (67%)