Protein Alignment CG17752 and SLC22A25

DIOPT Version :10

• Sequence 1: NP_650817.1
• Gene: CG17752 / 42337
• FlyBaseID: FBgn0038718
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_955384.3
• Gene: SLC22A25 / 387601
• HGNCID: 32935
• Length: 547
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 131/552 - (23%)
• Similarity: 226/552 - (40%)
• Gaps: 70/552 - (12%)

  Fly     1 MDLQRVLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLI----SFTPSHRCSAPVEE------ 55
            |..|.:|::.|..|.:|||.:......|::    .:.||.:    :|...|||...:.:
Human     1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVI----VYHQTQLENFAAFILDHRCWVHILDNDTIPD 61

  Fly    56 -----FSQNFTELLSCSVIQYDVDMTSFRDNKC-----------------------------SSW 86
                 .||:  .||..| |.:|   ::.|..||                             ..|
Human    62 NDPGTLSQD--ALLRIS-IPFD---SNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120

  Fly    87 DFDKESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGAS 151
            .:|:.|...:|.|:.:.||:.....:|.:..|..|..:|...:|:|:||.||......|.|..|.
Human   121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSYLQLAI 185

  Fly   152 GDFFTSFVGSLPMFSFTRFISGLSMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYSIGLMISP 216
            .....:|..::.::...||::|.:..:..|...:|:.|:::.|.....|.:.| ...|||.:...
Human   186 VGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTL-CAASIGHITLG 249

  Fly   217 WIAIWLGNWRSYLWAASLPALGMLIFPLFLHESVEWLLTKGKFDKAVNNLKSVAKFNG-RQVEDS 280
            .:|..:.:........|.|.....:|..:|.||..||:...|.::.:..|:..|..|| :..||.
Human   250 SLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDI 314

  Fly   281 VFDEFIKH-YREKLNSAQKKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGIS 344
            :..|.:|. .:::|.:||||.|  ...:||.|.:.|....|.......||.|..|:.:::.:|.:
Human   315 LTMEVLKSTMKQELEAAQKKHS--LCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNN 377

  Fly   345 PFKLFSYSGFVVLPGGLSIILFQNKIGRKGMACASLLVGAFITATTGYLVGTLDPANYSVLLGFM 409
            .|.|.:..|.|.|..........|.:.|:    .|.::..|:.||. .|.....|.....|...:
Human   378 VFLLQTLFGAVTLLANCVAPWALNHMSRR----LSQMLLMFLLATC-LLAIIFVPQEMQTLRVVL 437

  Fly   410 VCLARFGAVVAYDAEAQYAAEIIPTSVRGRG---VANIHVVGNAFAFFSSYIIYLGTFYKPLPSL 471
            ..|....|.:..........|:||:.:|||.   ..|...:|.|.|   |.::.|..:.:|||.:
Human   438 ATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGGALA---SLMMILSIYSRPLPWI 499

  Fly   472 LISFLLIIGACLCLTLPETLHKQLPQTLEEGE 503
            :.....|:...:.|.||||.::.|..::::.|
Human   500 IYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	127/535 (24%)
SLC22A25	NP_955384.3	MFS_OAT	109..516	CDD:340932	100/417 (24%)