Protein Alignment CG17752 and SV2C

DIOPT Version :10

• Sequence 1: NP_650817.1
• Gene: CG17752 / 42337
• FlyBaseID: FBgn0038718
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 114/548 - (20%)
• Similarity: 188/548 - (34%)
• Gaps: 194/548 - (35%)

  Fly   116 SFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPMFSFTRFISGLSMDTQY 180
            |..::|..:|:.|:|.|||::||..:.::.........|.:|||.....|.|.|.:||..:....
Human   195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAI 259

  Fly   181 VLMYILVFEYLSPQHRTFGLNIILGVFYSIGLMIS---PWIAI----W---LG------NWRSYL 229
            ..::....|.|:.:.|...|: .|.:|:.||.:.:   .|..|    |   :|      :||.::
Human   260 PTVFSYFAEVLAREKRGEHLS-WLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFV 323

  Fly   230 WAASLPALGMLIFPLFLHESVEWLLTKGKFDKAVNNLKSVAKFN--GRQVEDSVF---------- 282
            ...:||.:..::...|:.||..:||..||.|:|...||.:...|  .|...:.||
Human   324 IVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQ 388

  Fly   283 -DEFIK-------HYRE---KLNSAQKKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFD---- 332
             ||.|:       .||.   ::.:.......|||.....| :|..||.|.|  :..|::|.
Human   389 IDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRDNTIKLTI--VWFTLSFGYYGL 450

  Fly   333 -----------------ILSRNVEG---------------------------VGI---------- 343
                             :|:||||.                           :|:
Human   451 SVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDS 515

  Fly   344 --------------------------------SPFKLF----------------------SYSGF 354
                                            .|:|..                      .||.:
Human   516 VFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAY 580

  Fly   355 -----------VVLPGGLSIILFQNKIGR----------KGMACASLLVGAFITATTGYLVGTLD 398
                       .||||.:...|..::|||          .|::|..|..|
Human   581 WIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFG--------------- 630

  Fly   399 PANYSVLLGFMVCLARFGAVVAYDAEAQYAAEIIPTSVRGRGVANIHVVGNAFAFFSSYII-YLG 462
             .:.|:::| |:||.....:.|:::......|:.||..|..|...::.:..|.|...:.|. .|.
Human   631 -TSESMMIG-MLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV 693

  Fly   463 TFYKPLPSLLISFLLIIGACLCLTLPET 490
            :..|.:|.||.|.:|:.|..:.|.||:|
Human   694 SITKSIPILLASTVLVCGGLVGLCLPDT 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	114/548 (21%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	114/548 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		2/43 (5%)