DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	136/536 - (25%)
Similarity:	228/536 - (42%)	Gaps:	72/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQ-----ILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDYQPNST 60
            |....:|::.|:.||:|     :|.|.:.|..|     |...|...:.||.|.|..|    ||::
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALPVLGIAN-----HNLLQIFTATTPVHHCRPP----PNAS 56

  Fly    61 SLLSCSVMQFD---KEFKCTSW----------DFER-----------ESNYESITTELEWVCDDA 101
              :...|:..|   |..||..:          |.:|           .|..::|..|.:.||...
  Rat    57 --IGPWVLPLDPNGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCSSN 119

  Fly   102 YKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPWFSFTRF--- 163
            ....:.||.|..|..:|....|.|:||.||.|....|.|..|:.....:|..|||.:...||
  Rat   120 KLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCG 184

  Fly   164 --ISGLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAAS 226
              |||:.:.|     .||..|::....|... :..:|..|.:|..|...:|..:..||.....:|
  Rat   185 CSISGISLST-----VILNVEWVPTSMRAIS-STSIGYCYTIGQFILSGLAYAIPQWRWLQLTSS 243

  Fly   227 LPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDS--VFDEFIKHYREKLNNS 289
            .|.....|...::.||..||:..||:.||.|:|:.||.|||::.:..  ..:|...:.::.:.::
  Rat   244 APFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSA 308

  Fly   290 QNK--SSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCYLPA 352
            :.|  .||.|    |...||:.|..|.:.......|:..|:..||..|::.:.|....|...:||
  Rat   309 KVKYGLSDLF----RVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPA 369

  Fly   353 GLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATL-DPSDYSVLLGFMVSLGRYGAVVAYDA 416
            ....||..:.:||:      :....::..|.|.::|.: .||:..:|...:...|:.....::..
  Rat   370 KFITILSLSYLGRR------ITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSC 428

  Fly   417 EAQYAAEIIPTSVK--GRGVANIHV-VGNAFAFFSSYIIYLGTFYKPLPSLMISFILLIGACLCL 478
            ...|.:|:.||.::  |.|::|:.. ||:..|   ..:...|.....:|:::.....|:|.....
  Rat   429 LFLYTSELYPTVLRQTGMGISNVWARVGSMIA---PLVKITGELQPFIPNVIFGTTALLGGSAAF 490

  Fly   479 ALPETLHKNLPQNLEE 494
            .|.|||::.||:.:|:
  Rat   491 FLLETLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	132/520 (25%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	97/384 (25%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	133/521 (26%)
		MFS	124..492	CDD:119392	98/386 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950