DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_072146.1	Gene:	Slc22a23 / 64559	RGDID:	620302	Length:	689	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	111/495 - (22%)
Similarity:	194/495 - (39%)	Gaps:	94/495 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DKEFKCTSWDFE-RESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPA 134
            |...:|.:||:. |....:::.::.:.|||:|:|:.|.:....:|...|.:..|.:||.:||.|.
  Rat   190 DSNCECHAWDYGIRTGLVQNVVSKWDLVCDNAWKVHVAKFSLLVGLIFGYLITGCIADWVGRRPV 254

  Fly   135 CVLSTLTGASGDFFTSFVG-------SLPWFSFTRFISGLFMDTQYVLMYILVFEYLSPQHRTFG 192
            .:.|.:       |....|       ::..||..||..|..:....:.:|.|..| |.|..:.|.
  Rat   255 LLFSVI-------FILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIE-LCPPGKRFI 311

  Fly   193 LNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEK 257
            :.::.......|..:.|.:|....:|:........|.|.|||:.....||..||:...:||.|:|
  Rat   312 ITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKK 376

  Fly   258 SLRGVAKFNGRQVDDSVFDEFIKHYREKLNN--SQNKSSDTFMGMLRTPRLRKFTIILLIKSMII 320
            .:..:.:.|....:..     ||....:|..  |:.......:.::.|..|.|..::|.:.|:..
  Rat   377 LILYLTQKNCVSPESD-----IKGVMPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTG 436

  Fly   321 TIAFDILSRNVEGVGISPFKLFSYSGFCY------LPAGLTIILFQNKIGRKGMACASLFVGAII 379
            .......:|::.|..:....|.::....|      |.:.|.:.|....:||:|    .|.:..|:
  Rat   437 YGIHHCFARSMMGHEVKVPLLENFYADYYTMASIALASCLAMCLVVRFLGRRG----GLLLFMIL 497

  Fly   380 TAATGYLVATLDPSDYSVLLGFMVSLGRYG-----------AV-----------VAYDAEAQYA- 421
            ||....|           .||.:..:|:|.           ||           :|:.....:|
  Rat   498 TALASLL-----------QLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFAS 551

  Fly   422 -----------AEIIPTSVKGRGVANIHVVGNAFAFFSSYIIYL----GTFYKPLPSLMISFILL 471
                       |||.||.::..|:..: :....|...::.||.|    |.|   |..::.:...|
  Rat   552 HAVGSLSVFFCAEITPTVIRCGGLGLV-LASAGFGMLTAPIIELHNQKGYF---LHHIIFACCTL 612

  Fly   472 IGACLCLALPETLHKNLPQNLEEGEMFA--------KGEK 503
            |.....|.|||:..:|||:|:..||.:.        |||:
  Rat   613 ICIICILLLPESRDQNLPENIANGEHYTRQPLLSHKKGEQ 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	104/472 (22%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	88/424 (21%)
Slc22a23	NP_072146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188
		MFS_SLC22A23	187..608	CDD:341002	96/449 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030