DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	547	Identity:	128/547 - (23%)
Similarity:	221/547 - (40%)	Gaps:	70/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTII-SFT---PSHRC------------ 49
            |....:||:.|..|.:|.|.:    .|.|:..|...||.:: :|:   |.|||
Human     1 MAFSKLLEQAGGVGLFQTLQV----LTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVS 61

  Fly    50 --------------------------SRPEDYQ---PNSTSLLSCSVMQFDKEFKCTSWDFERES 85
                                      .|...:|   ||:|   :.|..:.|.|.....|.::|..
Human    62 TNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNAT---ATSWSEADTEPCVDGWVYDRSV 123

  Fly    86 NYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLP----ACVLSTLTGASGD 146
            ...:|..:.:.||.......:.||.|..|..:||..:|.|:.|.||.|    .|:...:.|.|..
Human   124 FTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTI 188

  Fly   147 FFTSFVGSLPWFSFTRFISGLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWI 211
            |..:||    .:...||::...|...::....|:.|:.:...|...:.:: |..:..|......:
Human   189 FAPTFV----IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVV-GCAFSAGQAALGGL 248

  Fly   212 AIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNG-RQVDDSVF 275
            |..:.:||....|||:|...:.|...:|.|||.||:.|||.::|.:.||.||:.|| ::..:...
Human   249 AFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTI 313

  Fly   276 DEFIKHYREKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFK 340
            :..:...:|::.::  |...:.:.:...|.||..:..:|:.:..:.|::..|..:::.:|...|.
Human   314 EVLMSSVKEEVASA--KEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFL 376

  Fly   341 LFSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSL 405
            |.:..|........|..|..:.:||:     ::..|:...|....|...|.|.|...|......|
Human   377 LQALFGAVDFLGRATTALLLSFLGRR-----TIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVL 436

  Fly   406 GRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLMISFIL 470
            |:....::......|.||:.||.|:......:|.||...|.....|:........||.|:...|.
Human   437 GKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVIS 501

  Fly   471 LIGACLCL-ALPETLHKNLPQNLEEGE 496
            :..:.:.| .||||....||..:::.|
Human   502 IASSLVVLFFLPETQGLPLPDTIQDLE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	123/529 (23%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	90/377 (24%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	124/530 (23%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950